{"id":"W2158091767","doi":"10.1080/10799890600923195","title":"The Active and the Inactive Form of the hAT<sub>1</sub>Receptor Have an Identical Ligand-Binding Environment: An MPA Study on a Constitutively Active Angiotensin II Receptor Mutant","year":2006,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Mutant; Receptor; Mutagenesis; G protein-coupled receptor; Ligand (biochemistry); Biochemistry; Chemistry; Angiotensin II; Angiotensin II receptor type 1; Amino acid; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009767287,0.0002893706,0.0003861525,0.00007782385,0.0009037097,0.00008820786,0.0002188379,0.0001797142,0.00001863655],"category_scores_gemma":[0.00005002245,0.0001545445,0.0002346757,0.0001052322,0.0007205628,0.00008603057,0.00005372662,0.0004272842,4.719617e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007458011,"about_ca_system_score_gemma":0.00008123683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003235312,"about_ca_topic_score_gemma":0.00003819976,"domain_scores_codex":[0.9978389,0.0005035357,0.0005841,0.000345678,0.000458935,0.0002688121],"domain_scores_gemma":[0.9987946,0.0001080067,0.0006061822,0.0001941123,0.0001778668,0.0001192735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003456808,0.0004020703,0.0002074061,0.000004377107,0.0002494201,0.000001273139,0.002643139,0.0000930392,0.977469,0.0004062707,0.00004327391,0.01502397],"study_design_scores_gemma":[0.002300566,0.003516827,0.001409682,0.00005874146,0.0001816721,0.00006530037,0.01359,0.00006301932,0.9769781,0.0005640514,0.001075107,0.0001969466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969156,0.000204228,0.001286999,0.0003381799,0.000574658,0.000605608,0.00004251448,0.000003824872,0.00002838674],"genre_scores_gemma":[0.9986975,0.0005864803,0.0001016918,0.00002436965,0.00051489,0.00001298889,0.00001084584,0.00002484719,0.00002643554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01482703,"threshold_uncertainty_score":0.6950696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008283958031702955,"score_gpt":0.2195497939733463,"score_spread":0.2112658359416433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}