{"id":"W2158091767","doi":"10.1080/10799890600923195","title":"The Active and the Inactive Form of the hAT<sub>1</sub>Receptor Have an Identical Ligand-Binding Environment: An MPA Study on a Constitutively Active Angiotensin II Receptor Mutant","year":2006,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Mutant; Receptor; Mutagenesis; G protein-coupled receptor; Ligand (biochemistry); Biochemistry; Chemistry; Angiotensin II; Angiotensin II receptor type 1; Amino acid; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023412,0.00017949,0.0001831822,0.00008523361,0.0001245736,0.0001847416,0.000263215,0.0001696943,0.000524912],"category_scores_gemma":[0.00007392882,0.00007674452,0.0001847236,0.00007053803,0.0002028552,0.0001843156,0.00009294133,0.0004191381,0.0001545964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427556,"about_ca_system_score_gemma":0.00007302022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007395289,"about_ca_topic_score_gemma":0.0004806735,"domain_scores_codex":[0.9999311,0.00001067291,0.000006253013,0.00001536078,0.00002242962,0.00001424721],"domain_scores_gemma":[0.9999421,0.00001528181,0.00001312982,0.000006239405,0.000006872175,0.00001633185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007503389,0.0000167205,0.0001555315,0.000008158499,0.000002549813,0.00007272313,0.00001193145,0.00005527299,0.9990805,0.0001676029,0.000008431811,0.0003454734],"study_design_scores_gemma":[0.00002360702,0.0005067085,0.007111607,0.000003731626,0.00003283613,0.001118671,0.00008692577,0.003319145,0.9858365,0.0001280802,0.001822346,0.000009857042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983881,0.0002447125,0.0009425218,0.00002624577,0.000004094584,0.000003759488,0.00005542776,0.000003933936,0.000331319],"genre_scores_gemma":[0.9977871,0.0002308291,0.0009903767,0.00001942306,0.000003313031,0.000004138272,0.0001584488,0.000006369557,0.0008000784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007395289,"threshold_uncertainty_score":0.001761317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008283958031702955,"score_gpt":0.2195497939733463,"score_spread":0.2112658359416433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}