{"id":"W2158092720","doi":"10.1172/jci28941","title":"Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":487,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Directorate for Biological Sciences; Henry Smith Charity","keywords":"FOXP3; Biology; IL-2 receptor; Population; Telomere; Cell biology; Immunology; T cell; Genetics; Immune system; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002444842,0.0001742884,0.000156422,0.0002361756,0.000121648,0.0002329481,0.0001315559,0.0001747682,0.001472922],"category_scores_gemma":[0.0002091178,0.0001375533,0.0001286236,0.00009470975,0.0001551023,0.0001544136,0.0001444863,0.0002357761,0.0003778037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177545,"about_ca_system_score_gemma":0.0001313022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261022,"about_ca_topic_score_gemma":0.0003941529,"domain_scores_codex":[0.9998945,0.00001664292,0.000007355499,0.00002914052,0.00002533702,0.00002695183],"domain_scores_gemma":[0.9999192,0.00002331828,0.00002131085,0.000015694,0.000007211352,0.00001337414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002196719,0.00001514821,0.0007782405,0.00002833496,0.000003924846,0.00005955385,0.0000337945,0.00006475251,0.991614,0.0001522871,0.00005834658,0.006972059],"study_design_scores_gemma":[0.00005586622,0.0007159525,0.01022271,0.00001433129,0.00003184519,0.0008730309,0.0000439638,0.0007877488,0.9792747,0.0002746799,0.007695994,0.000009067546],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840029,0.003257676,0.009195675,0.00007565462,0.00002132154,0.00003843409,0.0001876013,0.0001714678,0.003049249],"genre_scores_gemma":[0.9908627,0.0008661769,0.004471056,0.00006366777,0.00001561499,0.00004970059,0.0004103779,0.00003217437,0.003228551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472922,"threshold_uncertainty_score":0.004927397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05413647620024828,"score_gpt":0.3129438192656384,"score_spread":0.2588073430653901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}