{"id":"W2158092720","doi":"10.1172/jci28941","title":"Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":487,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Directorate for Biological Sciences; Henry Smith Charity","keywords":"FOXP3; Biology; IL-2 receptor; Population; Telomere; Cell biology; Immunology; T cell; Genetics; Immune system; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001229433,0.0001749687,0.0007153471,0.0002146931,0.00009602844,0.000009583047,0.0002569816,0.0005909117,0.0004231107],"category_scores_gemma":[0.0002651321,0.0001529369,0.0002843043,0.0001784565,0.000714621,0.0002096286,0.00004651541,0.000764863,0.00002854202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004478571,"about_ca_system_score_gemma":0.0001223219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001603223,"about_ca_topic_score_gemma":0.0001530329,"domain_scores_codex":[0.9963592,0.0007231664,0.002379462,0.0002088589,0.00009211956,0.0002372385],"domain_scores_gemma":[0.9969301,0.0003138097,0.002231078,0.0002467996,0.0002330985,0.00004506345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008742388,0.000352719,0.03708976,0.00001618816,0.00006461822,0.000005731083,0.00006180577,0.0001170903,0.9240761,0.0003258837,0.03750103,0.0003016053],"study_design_scores_gemma":[0.003288802,0.0004224456,0.1711381,0.0001388273,0.00008778401,0.00003087524,0.0001183802,0.000008635104,0.8158783,0.004265485,0.004444614,0.0001777316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955816,0.001828924,0.00003954992,0.0005712325,0.00138294,0.0001318131,0.00001690954,0.00001433564,0.0004326885],"genre_scores_gemma":[0.9974253,0.00004347322,0.0002661528,0.0002579053,0.0001711041,0.000002195331,0.00003716242,0.00001673444,0.001779927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340484,"threshold_uncertainty_score":0.6236586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05413647620024828,"score_gpt":0.3129438192656384,"score_spread":0.2588073430653901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}