{"id":"W2158094911","doi":"10.1186/1471-2407-12-80","title":"Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells","year":2012,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Morgan Adams Foundation","keywords":"Medulloblastoma; PLK1; Cancer research; Biology; Clonogenic assay; Cell growth; Radiosensitivity; RNA interference; Apoptosis; Cell cycle; Medicine; Radiation therapy; Internal medicine; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116172,0.0001215069,0.0001068697,0.0000415564,0.00003831378,0.00001678403,0.00002777271,0.000124453,0.00001587726],"category_scores_gemma":[0.00001298127,0.0001235336,0.00003396449,0.00006125571,0.00004683855,0.00001658485,0.00005120222,0.00005892929,0.000003831276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002175177,"about_ca_system_score_gemma":0.00005140834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004299757,"about_ca_topic_score_gemma":0.001871963,"domain_scores_codex":[0.9992905,0.00006539591,0.0001229703,0.0002165633,0.00006617797,0.000238409],"domain_scores_gemma":[0.9997123,0.00001587085,0.00006256979,0.0001138567,0.00002564809,0.00006977801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004738608,0.00006527156,0.03433842,0.00006350622,0.000005189271,9.5615e-7,0.0001032547,0.00002813164,0.9640461,0.00001426618,0.0008813188,0.000406167],"study_design_scores_gemma":[0.0003936033,0.00004143479,0.02086361,0.0000177006,0.000013099,0.000004581038,0.00005583317,0.00005984448,0.9753977,0.000007858401,0.00298792,0.0001567902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952539,0.003136797,0.0008484455,0.00003408526,0.0002710891,0.0001491111,0.00005376336,0.000007561798,0.0002452966],"genre_scores_gemma":[0.9968749,0.002070729,0.0002561172,0.0002216315,0.0003119116,0.00003423686,0.00007002082,0.00001439453,0.0001460186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01347481,"threshold_uncertainty_score":0.5037553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005602493281556616,"score_gpt":0.2278989490327549,"score_spread":0.2222964557511983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}