{"id":"W2158133398","doi":"10.1586/14737159.7.1.33","title":"Preimplantation genetic diagnosis for monogenic diseases: overview and emerging issues","year":2006,"lang":"en","type":"review","venue":"Expert Review of Molecular Diagnostics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Preimplantation genetic diagnosis; Genetic testing; Biology; Disease; Multiplex; Genetics; Pregnancy; Medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287925,0.0009921994,0.001747256,0.003439514,0.0002947926,0.0009524467,0.001369738,0.002000369,0.004185196],"category_scores_gemma":[0.001310052,0.0003195873,0.000560324,0.003176647,0.0007899518,0.001986093,0.0004380949,0.00183746,0.003323548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007695532,"about_ca_system_score_gemma":0.001274935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456147,"about_ca_topic_score_gemma":0.002478973,"domain_scores_codex":[0.9995735,0.00009554109,0.0000603956,0.00007234946,0.0001700383,0.00002807379],"domain_scores_gemma":[0.9986477,0.0008402637,0.0001163966,0.00003018925,0.0002737658,0.0000916089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004855464,0.0000800439,0.0003216017,0.008889274,0.00006489934,0.0009482183,0.00005965219,0.0003002922,0.001136177,0.002008262,0.02657098,0.9595721],"study_design_scores_gemma":[0.00003569025,0.0001510643,0.002143482,0.005206309,0.0001185928,0.01131008,0.0001497578,0.0001707931,0.0006322303,0.00216961,0.9778817,0.00003058872],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007140714,0.9983266,0.0002262406,0.0003685036,0.0001449761,0.000003422656,0.000005731143,0.000007189025,0.0008459191],"genre_scores_gemma":[0.0004364884,0.9983277,0.0003701196,0.0002038263,0.0001880001,0.000005169664,0.00001340694,0.000001310387,0.000454025],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004185196,"threshold_uncertainty_score":0.01400089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03400874858485853,"score_gpt":0.3929112159102041,"score_spread":0.3589024673253455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}