{"id":"W2158207006","doi":"10.1097/00000542-200607000-00025","title":"Increased Prostaglandin E2Release and Activated Akt/β-Catenin Signaling Pathway Occur after Opioid Withdrawal in Rat Spinal Cord","year":2006,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Medicine; Protein kinase B; Prostaglandin E2; Opioid; Kindling; Morphine; Prostaglandin E; Spinal cord; Nociception; Pharmacology; Signal transduction; Endocrinology; Internal medicine; Stimulation; Receptor; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000988068,0.0003405129,0.0003411482,0.0003638183,0.0001996562,0.000204824,0.000127425,0.0002405071,0.001792591],"category_scores_gemma":[0.0001099777,0.0001841753,0.0002930178,0.0002254135,0.0003365189,0.0002981798,0.0001533882,0.0006103901,0.0001939284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385498,"about_ca_system_score_gemma":0.0002637345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263354,"about_ca_topic_score_gemma":0.002821738,"domain_scores_codex":[0.9999188,0.000005114686,0.000006047702,0.00001291809,0.00002388302,0.00003325856],"domain_scores_gemma":[0.9998891,0.00001117272,0.00004476286,0.000007680842,0.00001398661,0.00003323208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000719593,0.00004077429,0.0009047039,0.00005745695,0.000007908498,0.0001341369,0.0000242789,0.00001353272,0.9969389,0.00001970966,0.00001610761,0.001122841],"study_design_scores_gemma":[0.00007363401,0.002130367,0.09313378,0.00002328376,0.0000619395,0.000686887,0.0001766806,0.0003522458,0.9026356,0.00008316601,0.0006284011,0.00001395271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997629,0.001523339,0.0003836305,0.00004072701,0.00001008257,0.00001027869,0.0001580509,0.00001259725,0.0002322817],"genre_scores_gemma":[0.9967011,0.001190982,0.0005595783,0.00003465495,0.000006720571,0.00004512294,0.0002601251,0.000003553743,0.001198102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792591,"threshold_uncertainty_score":0.005996764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046114695757453,"score_gpt":0.2440770183231118,"score_spread":0.2336158713655373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}