{"id":"W2158214893","doi":"10.1128/cvi.00591-14","title":"Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial","year":2015,"lang":"en","type":"article","venue":"Clinical and Vaccine Immunology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Alberta","funders":"GlaxoSmithKline","keywords":"Medicine; Cohort; Vaccination; Confidence interval; Cervical cancer; Vaccine efficacy; HPV infection; Immunogenicity; Randomized controlled trial; Cervical intraepithelial neoplasia; Vaccine trial; HPV vaccines; Internal medicine; Young adult; Oncology; Gynecology; Cancer; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002068753,0.0002453004,0.00216787,0.0004523782,0.00008109967,0.00001655606,0.0001489349,0.0003483937,0.0007660001],"category_scores_gemma":[0.001152874,0.0001569543,0.0003362716,0.001062682,0.0003511755,0.00007482712,0.0003555846,0.0007510406,0.000001252753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147255,"about_ca_system_score_gemma":0.0001709741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162253,"about_ca_topic_score_gemma":0.002316885,"domain_scores_codex":[0.9964891,0.0007494684,0.001610224,0.0005077943,0.0002693613,0.0003740431],"domain_scores_gemma":[0.9976714,0.0009510071,0.0004146014,0.0004069815,0.0003341348,0.0002218663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6574678,0.0007890763,0.3050922,0.0000792764,0.001299809,0.000003542558,0.0002243354,0.000008485715,0.0001394885,0.00005471566,0.00008933737,0.034752],"study_design_scores_gemma":[0.4708457,0.00173243,0.5258145,0.0000254275,0.0007506098,0.000006036003,0.00006336105,0.0003171703,0.00006517213,0.0001722296,0.0001146042,0.00009282484],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939713,0.002933506,0.0000244552,0.0005681305,0.0002456197,0.001414235,0.00001114535,0.00001528374,0.0008162555],"genre_scores_gemma":[0.9951993,0.004113446,0.000007966239,0.0001076508,0.0002457211,0.00009657298,0.00004341809,0.0000164507,0.0001694254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2207223,"threshold_uncertainty_score":0.8387164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1191740909336267,"score_gpt":0.4325047168914288,"score_spread":0.3133306259578021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}