{"id":"W2158215331","doi":"10.1128/jb.00305-07","title":"Phosphorylated AbsA2 Negatively Regulates Antibiotic Production in<i>Streptomyces coelicolor</i>through Interactions with Pathway-Specific Regulatory Gene Promoters","year":2007,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Actinorhodin; Streptomyces coelicolor; Biology; Response regulator; Promoter; Two-component regulatory system; Regulation of gene expression; Chromatin immunoprecipitation; Regulator gene; Mutant; Gene; Transcriptional regulation; Regulon; Streptomyces; Signal transduction; Phosphorylation; Cell biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007872857,0.0005383947,0.0002046514,0.0002255987,0.0002102376,0.0003583061,0.0001594022,0.0001248483,0.001072259],"category_scores_gemma":[0.0001275763,0.0001810133,0.0001780177,0.0001129947,0.0002943832,0.00009613641,0.0002475249,0.0003025387,0.0004393863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005574575,"about_ca_system_score_gemma":0.0002432832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001670349,"about_ca_topic_score_gemma":0.002923821,"domain_scores_codex":[0.9998404,0.00003214004,0.000009940665,0.00003385673,0.00004774729,0.00003593823],"domain_scores_gemma":[0.9998535,0.00002546295,0.00003942275,0.00001454511,0.00001319068,0.00005382448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005760107,0.000009647656,0.0002127961,0.000007574294,0.000001204667,0.00002091085,0.000004909467,0.00003707552,0.9993643,0.00002697065,0.00001513405,0.0002419104],"study_design_scores_gemma":[0.00001704451,0.0001251327,0.01090717,0.000003533243,0.000006476386,0.000146224,0.00002856982,0.001682005,0.9860495,0.00003729452,0.0009917838,0.000005234958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971461,0.0003816961,0.0009296695,0.00004064876,0.00001012792,0.000007012657,0.0001661022,0.0001143085,0.001204417],"genre_scores_gemma":[0.9970778,0.0001382563,0.0007648123,0.00002561391,0.000005526801,0.000009844952,0.0004328481,0.00003394997,0.001511378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001670349,"threshold_uncertainty_score":0.004044592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562102828429806,"score_gpt":0.2482394698280488,"score_spread":0.2326184415437507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}