{"id":"W2158215331","doi":"10.1128/jb.00305-07","title":"Phosphorylated AbsA2 Negatively Regulates Antibiotic Production in<i>Streptomyces coelicolor</i>through Interactions with Pathway-Specific Regulatory Gene Promoters","year":2007,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Actinorhodin; Streptomyces coelicolor; Biology; Response regulator; Promoter; Two-component regulatory system; Regulation of gene expression; Chromatin immunoprecipitation; Regulator gene; Mutant; Gene; Transcriptional regulation; Regulon; Streptomyces; Signal transduction; Phosphorylation; Cell biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006975541,0.0002200475,0.0005879989,0.0003083266,0.0000744749,0.00001951338,0.0001106991,0.0001621335,0.0001030993],"category_scores_gemma":[0.000155822,0.0001453649,0.0001098267,0.0004188657,0.0002752456,0.0003227147,0.00002558767,0.0005567923,0.000008315041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220427,"about_ca_system_score_gemma":0.0001376294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002390741,"about_ca_topic_score_gemma":0.00003380871,"domain_scores_codex":[0.9982308,0.00009089847,0.000863386,0.0003274232,0.0001629712,0.0003245173],"domain_scores_gemma":[0.9983771,0.00007492524,0.0007734123,0.0002347764,0.0004395443,0.0001002833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002904489,0.0002790037,0.004708255,0.00004442591,0.0001489567,0.0002602738,0.0005335328,0.00001140127,0.9804704,0.00001110742,0.0006363976,0.009991712],"study_design_scores_gemma":[0.0008272681,0.00106132,0.2244574,0.000356408,0.00005096292,0.003406348,0.0002251986,0.000001679278,0.7607795,0.00003106456,0.008663719,0.00013912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948786,0.0006658595,0.00002319736,0.003056297,0.000886214,0.0003512591,0.000003398213,0.00002297536,0.0001122015],"genre_scores_gemma":[0.994449,0.0003049303,0.004191486,0.0001840851,0.0005976994,2.819186e-7,0.00001036078,0.0000250596,0.0002371336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2197492,"threshold_uncertainty_score":0.5927809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562102828429806,"score_gpt":0.2482394698280488,"score_spread":0.2326184415437507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}