{"id":"W2158233796","doi":"10.1038/nature10833","title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2682,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; McGill University Health Centre; Biotechnology Research Institute; McGill University; Montreal Children's Hospital; Hospital for Sick Children; McGill University and Génome Québec Innovation Centre","funders":"Canadian Institutes of Health Research; Brain Tumour Charity; Genome Canada; Cancer Research Institute","keywords":"ATRX; Death-associated protein 6; Biology; Histone; Histone H3; Chromatin; Telomere; Genetics; Mutation; Epigenetics; Gene; Germline mutation; Somatic cell; Chromatin remodeling; Cancer research; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679263,0.0002231345,0.0003187511,0.0007385074,0.0003212356,0.0003619951,0.0003412885,0.0006469205,0.001348866],"category_scores_gemma":[0.0008133844,0.0002666901,0.0002498616,0.0008853303,0.0004700611,0.0002764034,0.0004294759,0.0003459154,0.0001891425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006383455,"about_ca_system_score_gemma":0.0005432583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003533377,"about_ca_topic_score_gemma":0.005212942,"domain_scores_codex":[0.9998145,0.00001824927,0.00002283682,0.00002540559,0.00007195152,0.00004703075],"domain_scores_gemma":[0.9997399,0.00006262921,0.0001288358,0.000009705027,0.0000209908,0.00003791683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001218325,0.00009322427,0.6239343,0.000303808,0.000140177,0.1537623,0.0007638859,0.002849553,0.130166,0.00284472,0.003139257,0.08078454],"study_design_scores_gemma":[0.00005872927,0.0001652538,0.709547,0.0001030986,0.0001869608,0.2500702,0.0005871978,0.002020616,0.03076246,0.001575373,0.004888686,0.00003446505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949531,0.001773749,0.0004976426,0.0002672873,0.0000208494,0.000008787561,0.000217166,0.00002432867,0.002236966],"genre_scores_gemma":[0.9976652,0.001221956,0.0005133098,0.00005682274,0.00001330247,0.000004249648,0.0001548895,0.00001488223,0.0003554295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003533377,"threshold_uncertainty_score":0.007025599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008728974279584002,"score_gpt":0.2771505690127217,"score_spread":0.2684215947331377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}