{"id":"W2158245669","doi":"10.1093/hmg/ddq152","title":"The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by α-T-catenin upregulation","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Koninklijke Nederlandse Akademie van Wetenschappen","keywords":"Trophoblast; Biology; Downregulation and upregulation; Genotype; Cell biology; Protein kinase B; Allele; Catenin; Gene; Cytoplasm; Signal transduction; Genetics; Placenta; Fetus; Pregnancy; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893185,0.0001690645,0.0002193258,0.00005546441,0.0002551417,0.00002053839,0.0001323345,0.0001318226,0.00001294476],"category_scores_gemma":[0.00008668708,0.0001236843,0.00006389531,0.0002193272,0.0001846487,0.00002215632,0.0000603453,0.0002467892,0.000004908673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003374078,"about_ca_system_score_gemma":0.00005571415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001504646,"about_ca_topic_score_gemma":0.0001333037,"domain_scores_codex":[0.9988154,0.00007551925,0.0002677027,0.0002544796,0.0003544833,0.0002323754],"domain_scores_gemma":[0.9990879,0.00002833274,0.0001517115,0.0004380055,0.0002070535,0.00008694943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001807509,0.00008266371,0.004298237,0.00001957033,0.0001045235,0.00000346439,0.0007243607,0.0001384014,0.9918703,0.0002702612,0.0007370125,0.001570423],"study_design_scores_gemma":[0.001437358,0.001444747,0.4260058,0.0002371689,0.0002961911,0.00002522782,0.00008689873,0.0001451894,0.568036,0.000649631,0.001373708,0.0002621051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960886,0.001189304,0.001062547,0.0002899453,0.0001041086,0.0006051688,0.000006356826,0.00003977955,0.0006141883],"genre_scores_gemma":[0.9981259,0.00007214748,0.001047386,0.00006155459,0.00004756245,0.00003836356,0.00005730181,0.00003625413,0.0005135909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4238343,"threshold_uncertainty_score":0.50437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161971668475516,"score_gpt":0.2531323235487096,"score_spread":0.2415126068639545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}