{"id":"W2158316596","doi":"10.1074/jbc.m112.417477","title":"ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alberta Innovates; Canada Research Chairs; University of Alberta; Emory University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"GTPase; Biology; Protein family; Guanine nucleotide exchange factor; GTPase-activating protein; Conserved sequence; Genetics; SH3 domain; Protein domain; Homology (biology); Phylogenetics; Gene family; Phylogenetic tree; Sequence alignment; CDC42; Most recent common ancestor; Peptide sequence; Computational biology; Gene; Genome; G protein; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003414567,0.0001449995,0.0002130449,0.00002127322,0.00006930434,0.000007909833,0.00007392203,0.0002446785,0.0000181586],"category_scores_gemma":[0.0001230916,0.0001134767,0.0001461283,0.00005449859,0.000096182,0.00001683349,0.00002852506,0.0001228187,1.303888e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002058098,"about_ca_system_score_gemma":0.00005876922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.985776e-7,"about_ca_topic_score_gemma":7.462354e-8,"domain_scores_codex":[0.9990534,0.00002454337,0.0004281581,0.0001568121,0.0001427794,0.0001942705],"domain_scores_gemma":[0.9991805,0.00001618751,0.0004328089,0.00009008548,0.0001745641,0.0001058845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006801277,0.000268056,0.00422929,0.0001025871,0.00004652612,9.133507e-7,0.00001355296,0.000002018754,0.9943749,0.0000688512,0.00000695323,0.0002061952],"study_design_scores_gemma":[0.001102014,0.0003311612,0.02973641,0.00007879605,0.00001478204,0.00006598766,0.00008174877,0.0000161331,0.9615281,0.00009695336,0.006792506,0.000155466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496214,0.0006302797,0.04927142,0.00006112731,0.0000456036,0.0002427473,0.00006115516,0.000004370615,0.000061898],"genre_scores_gemma":[0.9930964,0.00004188572,0.005014506,0.00003080289,0.0006428343,0.00003071251,0.001053713,0.00001072394,0.00007848995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04425691,"threshold_uncertainty_score":0.4627447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856897329186148,"score_gpt":0.2314315058919757,"score_spread":0.2028625326001142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}