{"id":"W2158316596","doi":"10.1074/jbc.m112.417477","title":"ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alberta Innovates; Canada Research Chairs; University of Alberta; Emory University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"GTPase; Biology; Protein family; Guanine nucleotide exchange factor; GTPase-activating protein; Conserved sequence; Genetics; SH3 domain; Protein domain; Homology (biology); Phylogenetics; Gene family; Phylogenetic tree; Sequence alignment; CDC42; Most recent common ancestor; Peptide sequence; Computational biology; Gene; Genome; G protein; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009757555,0.0001880061,0.0001410841,0.0004156027,0.0001807769,0.0002098853,0.0001386097,0.0002174057,0.000442979],"category_scores_gemma":[0.0002057216,0.00007285364,0.0001846453,0.0002013525,0.0001363576,0.0001986903,0.000228352,0.0002593424,0.0002322996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482615,"about_ca_system_score_gemma":0.0001308647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003054494,"about_ca_topic_score_gemma":0.0004593442,"domain_scores_codex":[0.9999604,0.000005444926,0.000003376662,0.00001336107,0.00001025378,0.000007206129],"domain_scores_gemma":[0.9999156,0.00001544518,0.0000222497,0.000008922822,0.00001233954,0.00002532265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002265235,0.00003703468,0.008652279,0.00008205531,0.00001261413,0.0004504142,0.00009786674,0.0002138316,0.9837638,0.0002514177,0.00004423581,0.006167892],"study_design_scores_gemma":[0.00003774309,0.000594747,0.5074265,0.00006464163,0.0001123618,0.01184806,0.0007065167,0.007833519,0.4448954,0.0009618363,0.02548303,0.00003565471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972726,0.000623278,0.001194384,0.0000366274,0.000004581803,0.00001096637,0.0002698208,0.000009641098,0.0005781074],"genre_scores_gemma":[0.9926558,0.0005651423,0.00419968,0.00005148395,0.000008439953,0.00001442163,0.001696851,0.00001092371,0.0007973287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000442979,"threshold_uncertainty_score":0.00148195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856897329186148,"score_gpt":0.2314315058919757,"score_spread":0.2028625326001142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}