{"id":"W2158331775","doi":"10.1074/jbc.m115.669333","title":"Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Prostate Cancer Foundation; National Cancer Institute; National Institutes of Health; Prostate Cancer Canada; W. M. Keck Foundation","keywords":"PHD finger; Epigenetics; Histone; Chromatin; Histone methylation; Histone methyltransferase; Histone H3; Acetylation; Biology; Methylation; Cell biology; Homeobox; Biochemistry; Computational biology; Chemistry; DNA methylation; DNA; Gene expression; Gene; Transcription factor; Zinc finger","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389473,0.0002614664,0.0001334966,0.0001078824,0.00008729281,0.0001497992,0.0003060212,0.0001958841,0.0007655348],"category_scores_gemma":[0.00007431276,0.0001055714,0.0001663462,0.00005845002,0.0001703182,0.0001271028,0.0001183115,0.0003516858,0.0001331551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854512,"about_ca_system_score_gemma":0.0001753071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006123894,"about_ca_topic_score_gemma":0.0008515165,"domain_scores_codex":[0.9999496,0.00000807068,0.000003075766,0.000008543803,0.00001558227,0.00001513544],"domain_scores_gemma":[0.9999725,0.000008357197,0.000007565825,0.000002524922,0.000003027723,0.000006145367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000176209,0.00005261776,0.00006298224,0.00004874908,0.000009362046,0.00006439151,0.00001125392,0.0004428918,0.9961767,0.000814138,0.00006085162,0.002079753],"study_design_scores_gemma":[0.00004894612,0.0004033904,0.0004803237,0.000003348317,0.00001054013,0.00009413715,0.000007145153,0.001807396,0.9949517,0.0001306504,0.002058142,0.000004315007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840299,0.004625754,0.005534096,0.0002626691,0.00006449499,0.00006989998,0.0002292441,0.0000910551,0.005092842],"genre_scores_gemma":[0.9948838,0.001822217,0.00174734,0.00007295667,0.000008698088,0.00001954017,0.0000968437,0.000007001593,0.001341607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007655348,"threshold_uncertainty_score":0.002560973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883400997843624,"score_gpt":0.2572680597108016,"score_spread":0.2384340497323654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}