{"id":"W2158332203","doi":"10.1101/015412","title":"Systematic discovery and classification of human cell line essential genes","year":2015,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canada Research Chairs","keywords":"CRISPR; Biology; Gene; Computational biology; Genetics; RNA interference; Human genome; Context (archaeology); Genome; Genome editing; Function (biology); RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004445846,0.0002911815,0.0004089543,0.00204321,0.0002744494,0.0004512844,0.0002846968,0.0003236071,0.0009953765],"category_scores_gemma":[0.001031076,0.0001337847,0.0003277845,0.0008569387,0.0002251146,0.0001360773,0.0003864504,0.0003241848,0.0006268375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715225,"about_ca_system_score_gemma":0.0004452127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008887724,"about_ca_topic_score_gemma":0.00141779,"domain_scores_codex":[0.9996227,0.00004403167,0.0000521175,0.0001098971,0.000125712,0.0000455626],"domain_scores_gemma":[0.999132,0.0002897996,0.0001477934,0.0001516533,0.0001972546,0.00008156714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004199598,0.00004945102,0.02138017,0.0001336995,0.00004189943,0.0003943548,0.00006101374,0.0009524655,0.9511595,0.0007899384,0.0006074914,0.02400996],"study_design_scores_gemma":[0.00005523376,0.0003625189,0.09601763,0.0000435927,0.0001575908,0.00321794,0.0001101719,0.01009227,0.8642896,0.0009631575,0.02465132,0.00003894491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9229955,0.002500481,0.05234954,0.0001543063,0.00005262871,0.0002665366,0.01831165,0.0006490799,0.0027204],"genre_scores_gemma":[0.8845968,0.001346088,0.06681108,0.0001577369,0.00001244143,0.0001947775,0.04434311,0.0001675213,0.002370576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204321,"threshold_uncertainty_score":0.003329813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173730172087166,"score_gpt":0.2578478580840131,"score_spread":0.2461105563631414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}