{"id":"W2158342892","doi":"10.1371/journal.ppat.1000500","title":"NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Peptidoglycan; IRF3; Biology; Mycobacterium tuberculosis; Interferon regulatory factors; Pattern recognition receptor; NOD2; IRF5; Microbiology; Interferon; Innate immune system; TLR2; Cell biology; Immune system; Bacteria; Tuberculosis; Immunology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551669,0.0003924032,0.0001959079,0.0001562326,0.0002054153,0.0004088337,0.000175519,0.0003093784,0.001425768],"category_scores_gemma":[0.0001626291,0.0001417536,0.0001626747,0.00008447422,0.0002279603,0.000349159,0.0004000952,0.0004010749,0.0006478442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488251,"about_ca_system_score_gemma":0.0002742572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001280198,"about_ca_topic_score_gemma":0.0001813654,"domain_scores_codex":[0.9998722,0.00002506409,0.00001109312,0.00002497557,0.00002800563,0.00003866971],"domain_scores_gemma":[0.999926,0.000007421982,0.00002177798,0.00001190525,0.00000771335,0.00002508256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533428,0.00002849024,0.0005689528,0.00006454853,0.00000363403,0.0001567734,0.00001277265,0.0001129128,0.992999,0.0003961826,0.00008343511,0.005219994],"study_design_scores_gemma":[0.00009730882,0.0005501796,0.03263723,0.00005914436,0.00004556752,0.002871926,0.0002039156,0.002826722,0.9492714,0.001111298,0.01030874,0.00001650129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791148,0.01041385,0.004735427,0.0004226944,0.00005122374,0.00002293582,0.0002276859,0.0001295918,0.004881817],"genre_scores_gemma":[0.9940104,0.001669915,0.002185908,0.00005685097,0.00002175774,0.0000153311,0.0002508337,0.0000123248,0.001776544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425768,"threshold_uncertainty_score":0.004769683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074979859702394,"score_gpt":0.2475157043238006,"score_spread":0.2367659057267767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}