{"id":"W2158390960","doi":"10.1128/jvi.76.9.4181-4189.2002","title":"Cre Levels Limit Packaging Signal Excision Efficiency in the Cre/ <i>loxP</i> Helper-Dependent Adenoviral Vector System","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Helper virus; Biology; Cre recombinase; Virus; Virology; Vector (molecular biology); Transgene; Viral vector; Cloning (programming); Viral replication; Gene; Genetics; Recombinant DNA; Genetically modified mouse; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00118803,0.0004735274,0.0007144534,0.0003382325,0.0002370883,0.001337043,0.0007627251,0.0006534944,0.0009644777],"category_scores_gemma":[0.00100729,0.0004354518,0.0002938781,0.0002577389,0.0004845756,0.000810797,0.0004368001,0.001075636,0.0007677579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014933,"about_ca_system_score_gemma":0.0004997575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005516307,"about_ca_topic_score_gemma":0.0007601271,"domain_scores_codex":[0.9989963,0.0002247081,0.0001241493,0.0001589907,0.0003768407,0.0001190878],"domain_scores_gemma":[0.9992129,0.0003469199,0.0001624478,0.0001074014,0.0001150771,0.00005531306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001503713,0.0000137545,0.00008558293,0.00003245522,0.000002403164,0.00001955969,0.00001498338,0.0000429679,0.9986614,0.0001842674,0.00002167134,0.0009059887],"study_design_scores_gemma":[0.000004837904,0.00006755048,0.0004316687,0.000009117803,0.00001477796,0.0001321172,0.00001474339,0.0009630852,0.9957425,0.00009836171,0.002516366,0.00000480787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8523418,0.005851299,0.1354438,0.000329746,0.0001332152,0.0003785121,0.0005595081,0.0006656411,0.004296584],"genre_scores_gemma":[0.9139616,0.004517621,0.07358693,0.0002529815,0.0000339728,0.0002008271,0.001474881,0.0002410932,0.005730125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337043,"threshold_uncertainty_score":0.006282926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421955660782706,"score_gpt":0.2863617701458308,"score_spread":0.2521422135380037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}