{"id":"W2158395269","doi":"10.1095/biolreprod.115.129072","title":"Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries1","year":2015,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Ovarian function and disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Biology; Endocrinology; Internal medicine; Luteinizing hormone; Anovulation; Ovulation; Polycystic ovary; Aromatase; Follicle-stimulating hormone receptor; Estrous cycle; Anti-Müllerian hormone; Follicle-stimulating hormone; Hormone; Insulin resistance; Insulin; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005417211,0.001795399,0.0007967178,0.00297253,0.0006335682,0.000709017,0.0007919597,0.001275617,0.007293834],"category_scores_gemma":[0.0002651896,0.0009468681,0.0008466815,0.0008081228,0.001105496,0.0005387266,0.0007640925,0.001957559,0.002485657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005254048,"about_ca_system_score_gemma":0.0003272257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005452876,"about_ca_topic_score_gemma":0.001084957,"domain_scores_codex":[0.9992517,0.000106932,0.00009825613,0.0001946108,0.0002077457,0.0001406991],"domain_scores_gemma":[0.9992219,0.00009213553,0.0003542687,0.00006555493,0.00003013456,0.0002359509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003476916,0.0002131204,0.0005485705,0.00008724519,0.00002965465,0.0004463631,0.00006703773,0.00005369195,0.9950032,0.0005722325,0.0003610575,0.002270181],"study_design_scores_gemma":[0.0005451705,0.002066857,0.04114792,0.000164392,0.0002199957,0.008652103,0.0002112567,0.002140193,0.9262081,0.0007149993,0.01784838,0.00008073045],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554784,0.00730975,0.01227704,0.001183525,0.0004422082,0.0004037445,0.01061596,0.003251749,0.009037628],"genre_scores_gemma":[0.9480447,0.005250497,0.01004045,0.000638883,0.0001864299,0.0007248913,0.007982175,0.0008878938,0.02624395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007293834,"threshold_uncertainty_score":0.02440023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902271590045073,"score_gpt":0.2739155717868682,"score_spread":0.2448928558864175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}