{"id":"W2158395269","doi":"10.1095/biolreprod.115.129072","title":"Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries1","year":2015,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Ovarian function and disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Biology; Endocrinology; Internal medicine; Luteinizing hormone; Anovulation; Ovulation; Polycystic ovary; Aromatase; Follicle-stimulating hormone receptor; Estrous cycle; Anti-Müllerian hormone; Follicle-stimulating hormone; Hormone; Insulin resistance; Insulin; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008708574,0.00009910459,0.000214717,0.0002464779,0.00004022991,0.000007272873,0.00003298768,0.00009452392,0.000007076214],"category_scores_gemma":[0.0006666327,0.00007642033,0.00001934001,0.0005145792,0.0001283523,0.0001195054,0.00001441381,0.0001119877,0.000002858982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005316158,"about_ca_system_score_gemma":0.0001087053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005653796,"about_ca_topic_score_gemma":0.0001052496,"domain_scores_codex":[0.9988941,0.0001586498,0.0003543845,0.0003466433,0.0001333954,0.0001128304],"domain_scores_gemma":[0.9993194,0.00005013783,0.0001432218,0.0002467324,0.0001984221,0.00004204454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02089237,0.001368739,0.794639,0.0001857176,0.0001594568,0.00001224505,0.02060694,0.001609132,0.1207859,0.002875314,0.001691997,0.03517316],"study_design_scores_gemma":[0.002174168,0.001946694,0.9875,0.00003524408,0.00004648738,0.0001450076,0.002356893,0.0003595086,0.003465144,0.001128945,0.0007399592,0.0001019903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985168,0.001206956,0.008946581,0.0038602,0.0001467373,0.0005646639,0.000003987368,0.00001722663,0.00008565827],"genre_scores_gemma":[0.9971825,0.00001904885,0.002400381,0.0001616369,0.0000862744,0.0000309569,0.00008185828,0.000006545187,0.00003076057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192861,"threshold_uncertainty_score":0.3116331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902271590045073,"score_gpt":0.2739155717868682,"score_spread":0.2448928558864175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}