{"id":"W2158422264","doi":"10.1158/1541-7786.mcr-11-0423-t","title":"The Unliganded Glucocorticoid Receptor Positively Regulates the Tumor Suppressor Gene <i>BRCA1</i> through GABP Beta","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hormone response element; Glucocorticoid receptor; Transcription factor; Carcinogenesis; Cancer research; Downregulation and upregulation; Biology; Regulator; Gene expression; Regulation of gene expression; Glucocorticoid; Gene; Internal medicine; Endocrinology; Breast cancer; Cancer; Medicine; Genetics; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001202233,0.0002644391,0.0001953813,0.00003657884,0.0007510264,0.0001396894,0.0007517756,0.0002080381,0.00004334083],"category_scores_gemma":[0.0001413172,0.000155409,0.0002069304,0.0003795146,0.0005606943,0.00001514035,0.0004677068,0.0006220319,0.0001039173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007592119,"about_ca_system_score_gemma":0.0002415612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001881769,"about_ca_topic_score_gemma":0.00001256664,"domain_scores_codex":[0.996602,0.000742657,0.0002713447,0.0004752658,0.0007084003,0.00120033],"domain_scores_gemma":[0.9983705,0.0001339822,0.00009027876,0.0009380061,0.0002826264,0.0001846224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003201866,0.00007158658,0.0005450733,0.00001719191,0.0002870923,0.0000112585,0.0001565405,0.0000460937,0.9864953,0.0007001297,0.01059636,0.0007531772],"study_design_scores_gemma":[0.0005360863,0.0002264244,0.0007970242,0.0000252458,0.00003669581,0.00003278229,0.0001198905,0.00001843007,0.900605,0.000074248,0.09732231,0.000205908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9431518,0.05031309,0.0000962269,0.003338254,0.0004739357,0.0009906035,0.00002773697,0.00002104797,0.001587339],"genre_scores_gemma":[0.99382,0.002523151,0.0001298452,0.000675511,0.0005006039,0.000380934,0.000074468,0.00008048197,0.001815051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08672594,"threshold_uncertainty_score":0.6337394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149209389435929,"score_gpt":0.3300737302944772,"score_spread":0.3085816364001179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}