{"id":"W2158476520","doi":"10.1152/ajpregu.90335.2008","title":"Immune-to-brain signaling and central prostaglandin E<sub>2</sub>synthesis in fasted rats with altered lipopolysaccharide-induced fever","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Endocrinology; Lipopolysaccharide; Internal medicine; Prostaglandin E2; Immune system; Cytokine; SOCS3; Hypothalamus; Inflammation; Prostaglandin; Central nervous system; Receptor; Cyclooxygenase; Hypothermia; Receptor antagonist; Tumor necrosis factor alpha; Innate immune system; Chemistry; Biology; Medicine; Antagonist; Immunology; Enzyme; Suppressor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002969363,0.0005346229,0.001675142,0.00049518,0.0002944924,0.00001475407,0.0002678105,0.0001761737,0.00004173999],"category_scores_gemma":[0.0001184612,0.0003706133,0.0001549,0.0003688314,0.001662639,0.0003127722,0.00009867339,0.0007684504,0.0000190074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009984494,"about_ca_system_score_gemma":0.0002449809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001131381,"about_ca_topic_score_gemma":0.00004703936,"domain_scores_codex":[0.9962143,0.001618447,0.0008935641,0.0005355461,0.0000902606,0.0006478225],"domain_scores_gemma":[0.9974789,0.000863097,0.0009591085,0.0002645901,0.0003287272,0.0001055895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005676907,0.0001744605,0.001408951,0.00001160389,0.0005482658,0.000009370903,0.006636117,0.000118699,0.9829823,0.0003462204,0.0001868496,0.001900293],"study_design_scores_gemma":[0.001222552,0.002494803,0.3065444,0.0001519549,0.00004030067,0.0002067973,0.004068037,0.00002675105,0.684755,0.0001037854,0.00008209578,0.0003035848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982656,0.0006298862,0.0001060395,0.0003239588,0.0002159193,0.0004064435,0.00001325826,0.00001940909,0.0000195123],"genre_scores_gemma":[0.9992111,0.0001307005,0.0001628099,0.0002740899,0.0000910545,0.00005267258,0.00002171675,0.00002343839,0.00003238902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3051354,"threshold_uncertainty_score":0.9998746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706374987622137,"score_gpt":0.2409007919288104,"score_spread":0.223837042052589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}