{"id":"W2158491449","doi":"10.1186/2051-5960-1-24","title":"Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment","year":2013,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hersenstichting; Prinses Beatrix Spierfonds; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dalhousie University; Keio University; ALS Association","keywords":"Cell biology; Endoplasmic-reticulum-associated protein degradation; Proteasome; Biology; Mutant; Neurodegeneration; Motor neuron; Chaperone (clinical); Unfolded protein response; Ubiquitin ligase; Ubiquitin; Endoplasmic reticulum; Biochemistry; Neuroscience; Pathology; Medicine; Spinal cord; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127288,0.0003777991,0.0001851904,0.0002503619,0.0002453512,0.0003582018,0.0002435331,0.000395121,0.0008969564],"category_scores_gemma":[0.0001397582,0.0001595643,0.0002400917,0.0001548062,0.0003190375,0.0004124252,0.0005107828,0.0003357422,0.0004900168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884648,"about_ca_system_score_gemma":0.0001535057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004660441,"about_ca_topic_score_gemma":0.000435964,"domain_scores_codex":[0.9999082,0.000006687055,0.00001408695,0.00002333019,0.00003110762,0.00001655812],"domain_scores_gemma":[0.9998228,0.00001351759,0.0000859436,0.00001958253,0.00003247001,0.00002583679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007136738,0.000006878584,0.001231118,0.00004522473,0.000008578337,0.0003809361,0.0000167753,0.00004071117,0.9974253,0.00009516353,0.00001818633,0.000659837],"study_design_scores_gemma":[0.00002254172,0.0002644057,0.05333464,0.00003094604,0.0000431301,0.007473051,0.00008727354,0.001427684,0.9340219,0.0003912795,0.002888996,0.00001414226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994664,0.0007800783,0.003524819,0.00003876504,0.000009244583,0.00001442277,0.0002625989,0.00007936082,0.0006266213],"genre_scores_gemma":[0.9957557,0.0003778177,0.002619996,0.00001838154,0.000006025275,0.00001389058,0.0005044246,0.00001418914,0.0006896844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008969564,"threshold_uncertainty_score":0.003000617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1565299755034657,"score_gpt":0.3724873390817676,"score_spread":0.2159573635783019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}