{"id":"W2158491449","doi":"10.1186/2051-5960-1-24","title":"Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment","year":2013,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hersenstichting; Prinses Beatrix Spierfonds; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dalhousie University; Keio University; ALS Association","keywords":"Cell biology; Endoplasmic-reticulum-associated protein degradation; Proteasome; Biology; Mutant; Neurodegeneration; Motor neuron; Chaperone (clinical); Unfolded protein response; Ubiquitin ligase; Ubiquitin; Endoplasmic reticulum; Biochemistry; Neuroscience; Pathology; Medicine; Spinal cord; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00109151,0.0004133114,0.0008208257,0.0001994538,0.001300802,0.000197566,0.001775219,0.0002566999,0.00143821],"category_scores_gemma":[0.001318728,0.0003219901,0.0002808614,0.0005661556,0.0007661375,0.0004756714,0.001971245,0.001230021,0.0006519882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885788,"about_ca_system_score_gemma":0.0001167442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009252133,"about_ca_topic_score_gemma":0.00006277991,"domain_scores_codex":[0.9929415,0.003579689,0.001053415,0.0007756132,0.0007966589,0.0008531137],"domain_scores_gemma":[0.992185,0.0008887521,0.0003864138,0.005144238,0.0007300103,0.0006656048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002601183,0.006900274,0.1415962,0.00003149926,0.0002307447,0.00006933903,0.0009464804,0.00007146552,0.8389746,0.001318044,0.006672571,0.002928679],"study_design_scores_gemma":[0.002189968,0.0007227469,0.9902231,0.00007339836,0.0001041791,0.00004199247,0.00006002372,0.003532598,0.0001376219,0.0006450854,0.001936619,0.0003327423],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517847,0.0001878973,0.00005617456,0.04240264,0.0000863208,0.001996123,0.00009757929,0.0004835015,0.002905055],"genre_scores_gemma":[0.991502,0.001286103,0.001694218,0.003621537,0.00007092024,0.0007680742,0.0004051664,0.00006654825,0.0005854475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8486269,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1565299755034657,"score_gpt":0.3724873390817676,"score_spread":0.2159573635783019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}