{"id":"W2158512646","doi":"10.1371/journal.pone.0103402","title":"KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Bundesministerium für Wirtschaft und Technologie; Forsknings- og Innovationsstyrelsen; Bayerische Forschungsstiftung; Danmarks Grundforskningsfond; Danish Agency for Science and Higher Education; National Research Foundation; Deutsche Forschungsgemeinschaft; Hjerteforeningen","keywords":"BK channel; Potassium channel; Mitochondrion; Ischemia; Oxidative phosphorylation; Reperfusion injury; Mitochondrial ROS; Chemistry; Reactive oxygen species; Hypoxia (environmental); Calcium-activated potassium channel; Internal medicine; Pharmacology; Cardiology; Medicine; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668286,0.0003722422,0.0003949094,0.0001845196,0.0001388215,0.0002796489,0.0002199645,0.0003617102,0.00263995],"category_scores_gemma":[0.0001857864,0.0001408151,0.0001806792,0.0001296788,0.0002113632,0.00041251,0.0002005906,0.0007954134,0.0004327284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002026391,"about_ca_system_score_gemma":0.0001790939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113593,"about_ca_topic_score_gemma":0.0002494134,"domain_scores_codex":[0.9998735,0.00001273354,0.00001784905,0.00002861122,0.00002570766,0.00004146666],"domain_scores_gemma":[0.9997768,0.00002445921,0.00006108372,0.00002590948,0.00001817571,0.00009353863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003549067,0.00004809483,0.00007273817,0.00003278744,0.0000030036,0.0000150024,0.000008078212,0.00002069184,0.9986118,0.0000539042,0.00002694045,0.0007520529],"study_design_scores_gemma":[0.00005840806,0.0009251753,0.003842279,0.00000768853,0.00002917748,0.0001917232,0.00003025556,0.0006280685,0.9928083,0.00006636083,0.001405827,0.000006578675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953882,0.001075272,0.001933922,0.0001476692,0.0000816834,0.00002708382,0.0004155265,0.00013723,0.0007934831],"genre_scores_gemma":[0.9952537,0.0007072581,0.001242809,0.00005204567,0.00002429442,0.00002484489,0.0005873463,0.00003599004,0.002071656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00263995,"threshold_uncertainty_score":0.008831501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230010625656841,"score_gpt":0.2262530230009525,"score_spread":0.2032519604352684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}