{"id":"W2158512646","doi":"10.1371/journal.pone.0103402","title":"KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Bundesministerium für Wirtschaft und Technologie; Forsknings- og Innovationsstyrelsen; Bayerische Forschungsstiftung; Danmarks Grundforskningsfond; Danish Agency for Science and Higher Education; National Research Foundation; Deutsche Forschungsgemeinschaft; Hjerteforeningen","keywords":"BK channel; Potassium channel; Mitochondrion; Ischemia; Oxidative phosphorylation; Reperfusion injury; Mitochondrial ROS; Chemistry; Reactive oxygen species; Hypoxia (environmental); Calcium-activated potassium channel; Internal medicine; Pharmacology; Cardiology; Medicine; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004519116,0.0002795493,0.0006607832,0.0001579651,0.0001853549,0.00002988876,0.00009102977,0.0003403508,0.00009740936],"category_scores_gemma":[0.0003242658,0.0002362525,0.000302015,0.0002832623,0.00006911079,0.0001170751,0.0001273824,0.0004786147,0.0002341866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347685,"about_ca_system_score_gemma":0.00007703497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003189536,"about_ca_topic_score_gemma":9.489207e-7,"domain_scores_codex":[0.9979494,0.0000780306,0.0003436551,0.0005059664,0.0007217441,0.0004011647],"domain_scores_gemma":[0.9987227,0.00003731351,0.0001242247,0.0006265833,0.0002349465,0.0002542368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003052607,0.000637056,0.000846177,0.0003282912,0.0001488102,0.000004486242,0.0001979089,0.000002421166,0.9883041,0.00001499253,0.0009095488,0.008300976],"study_design_scores_gemma":[0.0009060747,0.0004848896,0.000006513169,0.0006160116,0.0003389258,0.000006144004,0.0000557006,0.00125604,0.9945203,0.00002214771,0.001504668,0.0002825848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846107,0.0002624515,0.0001622944,0.000963515,0.0004166058,0.001112334,0.000008179437,0.0002879627,0.01217592],"genre_scores_gemma":[0.9928705,0.000295806,0.0008571281,0.0003462463,0.001801732,0.0001802483,0.00008481875,0.00006416676,0.00349932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008676602,"threshold_uncertainty_score":0.9634098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230010625656841,"score_gpt":0.2262530230009525,"score_spread":0.2032519604352684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}