{"id":"W2158539944","doi":"10.1210/me.2005-0040","title":"Functional Genomics Identifies a Mechanism for Estrogen Activation of the Retinoic Acid Receptor α1 Gene in Breast Cancer Cells","year":2005,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Pediatric Oncology Group","funders":"University of California, Santa Cruz","keywords":"Biology; Breast cancer; Mechanism (biology); Retinoic acid; Estrogen receptor; Functional genomics; Cancer research; Genomics; Retinoic acid receptor; Gene; Estrogen receptor alpha; Genetics; Estrogen; Cancer; Computational biology; Cell biology; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009759481,0.0002073277,0.0002150199,0.0002251676,0.0001102671,0.0002104588,0.0001747808,0.0002151428,0.001074066],"category_scores_gemma":[0.00009793107,0.0002081767,0.0003994592,0.000123855,0.0001504641,0.0001214056,0.0001583962,0.0004487259,0.0007357909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368748,"about_ca_system_score_gemma":0.0001357834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003071129,"about_ca_topic_score_gemma":0.0003429475,"domain_scores_codex":[0.9999189,0.00001250543,0.000003387382,0.00002855301,0.00001851001,0.0000181931],"domain_scores_gemma":[0.9999368,0.00001248599,0.0000160997,0.00001362175,0.000009608169,0.00001136008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002213997,0.000004839304,0.0001754177,0.000009909515,0.000002407289,0.00002122589,0.000006269457,0.00003387634,0.9987663,0.00009396616,0.000009699886,0.0008539882],"study_design_scores_gemma":[0.00001514816,0.0001988003,0.02661403,0.000008401712,0.00002551681,0.0005628724,0.00003663951,0.001336421,0.9676076,0.0002055956,0.003384038,0.000004986317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737178,0.00201696,0.02042672,0.0002087963,0.00003021899,0.00005379498,0.0005387782,0.0002683436,0.002738676],"genre_scores_gemma":[0.9874471,0.000738332,0.007336445,0.0001075322,0.00001317132,0.00003866868,0.0009540441,0.00003482208,0.003329832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074066,"threshold_uncertainty_score":0.003593147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005874013210008678,"score_gpt":0.2198031419139666,"score_spread":0.2139291287039579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}