{"id":"W2158555441","doi":"10.1161/01.atv.0000047460.27435.b8","title":"Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C ( <i>LMNA</i> ) With Partial Lipodystrophy","year":2003,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"LMNA; Internal medicine; Endocrinology; Missense mutation; Insulin resistance; Adiponectin; Lipodystrophy; Biology; Insulin; Medicine; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220977,0.00018681,0.0002445481,0.00005230615,0.0001275335,0.0000247559,0.0001004084,0.0001746255,0.000008354925],"category_scores_gemma":[0.00004794987,0.00013282,0.00006251464,0.0001422789,0.000356191,0.00001166084,0.0000397278,0.0001115374,3.628688e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006544781,"about_ca_system_score_gemma":0.00002407359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007595359,"about_ca_topic_score_gemma":0.0001423114,"domain_scores_codex":[0.9988455,0.0002617234,0.0002092715,0.0003663193,0.00007645837,0.0002407615],"domain_scores_gemma":[0.9994416,0.00001889481,0.0001029225,0.0003330359,0.00004878365,0.0000548242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000009962831,0.00003540754,0.179926,0.00001245802,0.0001151867,1.76308e-7,0.0003736822,0.00000494745,0.8192866,0.0001647011,0.000007166224,0.00006376201],"study_design_scores_gemma":[0.001151841,0.000838871,0.8622818,0.00002825921,0.00009464745,0.000003942553,0.0008140567,0.00002690505,0.1339663,0.00007536936,0.0005204039,0.0001976615],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990336,0.00006623405,0.0003396867,0.00007611865,0.00004134188,0.000344528,0.00003231893,0.000006234797,0.0000598921],"genre_scores_gemma":[0.998688,0.0001172882,0.0009441064,0.0001036345,0.00003259499,0.00004906951,0.00004618645,0.00001764019,0.000001442266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6853203,"threshold_uncertainty_score":0.5416242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009738507019853924,"score_gpt":0.2146083666957355,"score_spread":0.2048698596758815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}