{"id":"W2158556448","doi":"10.3389/fnene.2013.00007","title":"Natural selection of mitochondria during somatic lifetime promotes healthy aging","year":2013,"lang":"en","type":"article","venue":"Frontiers in Neuroenergetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"H. Lundbeck A/S; Nordea-fonden; Lundbeckfonden; National Institutes of Health; Aarhus Universitet","keywords":"Mitochondrial biogenesis; Mitochondrion; Biology; Mitochondrial DNA; Biogenesis; Genome; Phenotype; Natural selection; Somatic cell; Genetics; TFAM; Mitochondrial fission; mitochondrial fusion; Cell biology; Selection (genetic algorithm); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003034579,0.00009573354,0.0001585647,0.0001786889,0.0001758262,0.0002587602,0.0001943904,0.0002148857,0.0009084204],"category_scores_gemma":[0.0003919508,0.00008284103,0.0001140786,0.00009668795,0.0002728983,0.0001856034,0.0003444678,0.0002409763,0.0001759323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713415,"about_ca_system_score_gemma":0.0001136875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001642719,"about_ca_topic_score_gemma":0.0006100778,"domain_scores_codex":[0.9998883,0.00001921771,0.000006722377,0.00004578354,0.0000207019,0.00001929338],"domain_scores_gemma":[0.9996829,0.00003665645,0.0001112437,0.00005406045,0.00003279098,0.00008248582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002931051,0.00006549515,0.02616258,0.00004574592,0.00003219248,0.000201842,0.0001305407,0.0002203144,0.9563157,0.001066796,0.0001692331,0.01529659],"study_design_scores_gemma":[0.00005142705,0.001491705,0.8129927,0.00002853083,0.00009742373,0.002861531,0.0003779979,0.004059959,0.1671484,0.004635536,0.006212108,0.00004270916],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961675,0.0005339409,0.002334381,0.0001236662,0.00001234578,0.000005703237,0.00006098619,0.00004705749,0.0007144381],"genre_scores_gemma":[0.9986688,0.0001787724,0.0006198687,0.00003950212,0.00001184266,0.000006124445,0.00006041118,0.00000704586,0.0004077083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009084204,"threshold_uncertainty_score":0.003039002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004384938802474606,"score_gpt":0.2107545168938625,"score_spread":0.2063695780913879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}