{"id":"W2158556448","doi":"10.3389/fnene.2013.00007","title":"Natural selection of mitochondria during somatic lifetime promotes healthy aging","year":2013,"lang":"en","type":"article","venue":"Frontiers in Neuroenergetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"H. Lundbeck A/S; Nordea-fonden; Lundbeckfonden; National Institutes of Health; Aarhus Universitet","keywords":"Mitochondrial biogenesis; Mitochondrion; Biology; Mitochondrial DNA; Biogenesis; Genome; Phenotype; Natural selection; Somatic cell; Genetics; TFAM; Mitochondrial fission; mitochondrial fusion; Cell biology; Selection (genetic algorithm); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005243764,0.0001594252,0.0002162979,0.0001489364,0.00005702366,0.00001515669,0.0001446541,0.0001144262,0.0000327521],"category_scores_gemma":[0.0001395933,0.0001619783,0.00007441655,0.0001923701,0.00006099878,0.000008854028,0.00006028447,0.0001695161,0.000006839975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001881246,"about_ca_system_score_gemma":0.00004408383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001967193,"about_ca_topic_score_gemma":0.00001542771,"domain_scores_codex":[0.9987673,0.0001429174,0.0003530724,0.0003229806,0.0001163807,0.0002974188],"domain_scores_gemma":[0.9994739,0.000009233874,0.0001321673,0.0002273522,0.00008303574,0.00007435628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007239438,0.00006354373,0.04233303,0.00007855776,0.00001786368,0.000002873395,0.00005247101,0.0003158482,0.9483942,0.00001128622,0.008311109,0.000346829],"study_design_scores_gemma":[0.001957753,0.0007739908,0.03570045,0.00005743848,0.00002961833,0.0001018295,0.0001403125,0.006771443,0.9484946,0.0003234039,0.00516927,0.0004799475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926865,0.0005027227,0.003028576,0.0002962973,0.003023229,0.000313045,0.000002473948,0.00002123087,0.0001259719],"genre_scores_gemma":[0.9757344,0.0002081915,0.02203324,0.0002752425,0.0003633157,0.00004592246,0.00003578088,0.00003504497,0.001268872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01900467,"threshold_uncertainty_score":0.6605282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004384938802474606,"score_gpt":0.2107545168938625,"score_spread":0.2063695780913879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}