{"id":"W2158564605","doi":"10.1093/infdis/jir699","title":"The Setpoint Study (ACTG A5217): Effect of Immediate Versus Deferred Antiretroviral Therapy on Virologic Set Point in Recently HIV-1–Infected Individuals","year":2011,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Gilead Sciences; U.S. Public Health Service; Centers for Disease Control and Prevention; National Center for Research Resources; National Institute of Mental Health; ACT Government; Abbott Laboratories","keywords":"Medicine; Clinical endpoint; Antiretroviral therapy; Seroconversion; Internal medicine; Human immunodeficiency virus (HIV); Clinical trial; Randomized controlled trial; Viral load; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00144485,0.0002601288,0.0004915457,0.0002407442,0.0002664824,0.00001958182,0.0004042363,0.00009514555,0.0001764031],"category_scores_gemma":[0.0006730688,0.0001175732,0.00023595,0.0002646018,0.0003274415,0.00009654494,0.00008654689,0.0005424779,0.0001519645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001095612,"about_ca_system_score_gemma":0.0001101077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002201966,"about_ca_topic_score_gemma":0.00008154246,"domain_scores_codex":[0.9956568,0.003042556,0.0005571918,0.0001499217,0.0001560976,0.0004373729],"domain_scores_gemma":[0.9967593,0.002199676,0.0005063082,0.0003582484,0.0001107857,0.00006568054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02183355,0.002426276,0.9638747,0.000008617914,0.001628908,0.00006378943,0.002051178,0.00001898583,0.002313108,0.00001101379,0.0009332965,0.004836601],"study_design_scores_gemma":[0.02036312,0.04532714,0.9230711,0.00004208329,0.0002999188,0.00007161382,0.0005997968,6.66905e-7,0.009805866,0.0001476567,0.0001328512,0.0001382077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949117,0.003310899,0.000002112562,0.0000676209,0.0005280171,0.0007766051,0.0001079272,0.0000232454,0.0002718919],"genre_scores_gemma":[0.9982536,0.001584553,6.744244e-7,0.00002802806,0.00003048262,0.00002741128,0.00002427516,0.00001676969,0.00003418485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04290086,"threshold_uncertainty_score":0.4794496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02469050859150345,"score_gpt":0.2845209313829927,"score_spread":0.2598304227914893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}