{"id":"W2158617484","doi":"10.1371/journal.pone.0052977","title":"Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; National Key Research and Development Program of China; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Chromodomain; Histone H3; Chromatin; Histone; Histone methyltransferase; PHD finger; Biology; Heterochromatin protein 1; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288769,0.0003377668,0.0005815795,0.0001452523,0.0005742544,0.0006467316,0.0006079348,0.0005172868,0.002187039],"category_scores_gemma":[0.0003765088,0.0002590762,0.000210831,0.0003640435,0.0001987629,0.0002872011,0.0002414088,0.001214342,0.0003469887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001205397,"about_ca_system_score_gemma":0.0008894742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009557449,"about_ca_topic_score_gemma":0.01169576,"domain_scores_codex":[0.9998729,0.00001486215,0.000004746986,0.00002312348,0.00005918651,0.00002508037],"domain_scores_gemma":[0.9998914,0.00002832225,0.00001448743,0.000005172614,0.00002427882,0.00003626173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005049084,0.001136564,0.01709812,0.001814019,0.0006327301,0.003982965,0.001243735,0.02663375,0.8046511,0.01511694,0.06127721,0.06136387],"study_design_scores_gemma":[0.003501249,0.00123483,0.1346445,0.0003329303,0.0007020307,0.003378679,0.001837893,0.3035356,0.33076,0.007748198,0.2120295,0.0002946014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649432,0.01044348,0.003918474,0.001685472,0.0003545995,0.00008777915,0.005926396,0.0003950011,0.01224561],"genre_scores_gemma":[0.9723614,0.003643567,0.006078177,0.0002799641,0.00005320696,0.00006085316,0.01173819,0.00007052079,0.00571404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009557449,"threshold_uncertainty_score":0.01900363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164167708264165,"score_gpt":0.2462672602328874,"score_spread":0.2246255831502458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}