{"id":"W2158642448","doi":"10.1097/mjt.0b013e3181f05957","title":"The Relative Bioavailability of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules (EMBEDA®) and an Extended Release Morphine Sulfate Capsule Formulation (KADIAN®) in Healthy Adults Under Fasting Conditions","year":2010,"lang":"en","type":"article","venue":"American Journal of Therapeutics","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"","keywords":"Bioequivalence; Cmax; Bioavailability; Medicine; Naltrexone; Morphine; Pharmacokinetics; Crossover study; Pharmacology; Confidence interval; Opioid; Anesthesia; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006820332,0.0003133526,0.0006848076,0.0002790843,0.0002340774,0.00003209774,0.000136113,0.00009039266,0.00001632839],"category_scores_gemma":[0.000262054,0.0002259121,0.0001161832,0.0004612482,0.0008020015,0.0003624199,0.00004037178,0.000736801,0.000001229487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378853,"about_ca_system_score_gemma":0.0003063812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009194071,"about_ca_topic_score_gemma":0.0006557716,"domain_scores_codex":[0.9976152,0.0002170358,0.001043311,0.0003323516,0.0003961384,0.0003960059],"domain_scores_gemma":[0.9970805,0.0004360554,0.001167517,0.0004611943,0.0004626053,0.0003921122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05188899,0.009306999,0.2138047,0.0007304156,0.003646662,0.0004999751,0.03261099,0.00114156,0.3712237,0.00721907,0.00004724923,0.3078797],"study_design_scores_gemma":[0.01027615,0.007827823,0.9494925,0.0003386038,0.0006847108,0.000510895,0.007041286,0.01029526,0.004972419,0.008097943,0.00007620297,0.0003861784],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919755,0.001367864,0.0001817747,0.00573718,0.0001185066,0.00051093,0.00006504994,0.00001943768,0.00002377077],"genre_scores_gemma":[0.9945131,0.002166756,0.002783215,0.0003380173,0.00008811848,0.00001166962,0.00003489928,0.00004541769,0.00001880577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7356879,"threshold_uncertainty_score":0.9212427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438397681885067,"score_gpt":0.305125115754642,"score_spread":0.2907411389357913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}