{"id":"W2158645259","doi":"10.1093/infdis/jiq010","title":"Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors","year":2010,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Neuraminidase; Pandemic; Virology; Zanamivir; Neuraminidase inhibitor; Oseltamivir; Virus; Influenza A virus; Recombinant DNA; H5N1 genetic structure; Pandemic influenza; Biology; Microbiology; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005529137,0.0001304101,0.0003092038,0.000260694,0.0001646031,0.00002877449,0.0000792875,0.00005072136,0.00002301354],"category_scores_gemma":[0.00153854,0.00007938437,0.00007867561,0.0002352759,0.0001603074,0.0001922831,0.00006460123,0.0003000729,0.000003856863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004758729,"about_ca_system_score_gemma":0.0001621004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004547263,"about_ca_topic_score_gemma":0.000047596,"domain_scores_codex":[0.9986919,0.0001335353,0.0005391923,0.00009324479,0.0003760149,0.0001661123],"domain_scores_gemma":[0.9984518,0.0001842473,0.0003820628,0.000194305,0.0005898692,0.0001976826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008636748,0.0001568225,0.2251283,0.00005956149,0.00008634962,0.000008406781,0.0004641683,0.00000978538,0.7696198,0.00002112017,0.0002771334,0.003304943],"study_design_scores_gemma":[0.002149026,0.002037576,0.9291234,0.0002156693,0.0004151749,0.0002091998,0.0001395901,0.0000549149,0.0618888,0.00009938866,0.003521381,0.0001458747],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985202,0.0003802757,0.00002722844,0.0002519111,0.0004344428,0.0003174332,0.00001704196,0.00001867078,0.00003281346],"genre_scores_gemma":[0.9981422,0.0005667511,0.0000201705,0.0008340238,0.0003900508,0.000007000733,0.000002164831,0.00001651537,0.00002112017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7077309,"threshold_uncertainty_score":0.3237201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05792516533992956,"score_gpt":0.3530709011402542,"score_spread":0.2951457358003247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}