{"id":"W2158658018","doi":"10.1124/jpet.108.136432","title":"Derivatized 2-Furoyl-LIGRLO-amide, a Versatile and Selective Probe for Proteinase-Activated Receptor 2: Binding and Visualization","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Centers for Disease Control and Prevention; McMaster University","keywords":"Receptor; Agonist; Peptide; Oligopeptide; Ligand binding assay; HEK 293 cells; Chemistry; G protein-coupled receptor; Transfection; In vitro; Binding site; Ligand (biochemistry); Radioligand; Alexa Fluor; Biochemistry; Molecular biology; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000487845,0.000626635,0.0002828948,0.0001952118,0.0002183909,0.0002709073,0.0005861541,0.0007178269,0.002157508],"category_scores_gemma":[0.0001834657,0.0003035424,0.0002735732,0.00011883,0.0002629802,0.0004276327,0.0002295192,0.0006283689,0.0005629738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000446648,"about_ca_system_score_gemma":0.000221447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005118399,"about_ca_topic_score_gemma":0.0006221439,"domain_scores_codex":[0.9998286,0.00003574912,0.000005412531,0.00004369251,0.0000221447,0.00006444975],"domain_scores_gemma":[0.9999236,0.00002510337,0.00001741269,0.000009423967,0.000006316727,0.00001820857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058043,0.00001076014,0.00001940821,0.0000342138,0.000003812206,0.00006894913,0.00001533231,0.00006612561,0.9986718,0.000166048,0.00007567858,0.000762164],"study_design_scores_gemma":[0.00003846245,0.0002016017,0.0005568308,0.000004827345,0.00001188965,0.0005006473,0.00001474322,0.0009110008,0.9937946,0.00007064606,0.003885278,0.000009480216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9426797,0.003865817,0.04502187,0.000605653,0.0001043607,0.0000902287,0.0003369259,0.0004160747,0.006879245],"genre_scores_gemma":[0.9543268,0.002225022,0.0330956,0.0003000536,0.00006845052,0.0001484053,0.0006370413,0.00007067458,0.009127854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157508,"threshold_uncertainty_score":0.007217586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05073861760725232,"score_gpt":0.3592120010345018,"score_spread":0.3084733834272495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}