{"id":"W2158670312","doi":"10.1128/aac.01183-07","title":"Modulation of Gene Expression in Human Macrophages Treated with the Anti- <i>Leishmania</i> Pentavalent Antimonial Drug Sodium Stibogluconate","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Canada Research Chairs; Burroughs Wellcome Fund","keywords":"Sodium stibogluconate; Leishmania donovani; THP1 cell line; Biology; Amastigote; Meglumine antimoniate; Gene expression; Molecular biology; Leishmania; Gene expression profiling; Gene; Cutaneous leishmaniasis; Immunology; Cell culture; Leishmaniasis; Genetics; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348645,0.0001913671,0.0003696286,0.0003301565,0.0001643824,0.0002756295,0.00007878768,0.0002467593,0.0008680182],"category_scores_gemma":[0.0001158465,0.0001514443,0.0002424505,0.00041439,0.0002097557,0.0001039049,0.0001029716,0.0002518734,0.0003106028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176602,"about_ca_system_score_gemma":0.0001500981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004906356,"about_ca_topic_score_gemma":0.0006049852,"domain_scores_codex":[0.9998426,0.00003024255,0.0000107711,0.00004378907,0.00003090711,0.00004169064],"domain_scores_gemma":[0.9999113,0.00002584329,0.00001572167,0.000006766546,0.00002350221,0.0000168548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002839085,0.00001867559,0.0006815871,0.00003360757,0.000005838628,0.00004187135,0.00004750015,0.00002100642,0.9982784,0.00001113956,0.00001975836,0.0005566385],"study_design_scores_gemma":[0.00003841422,0.001292601,0.08143164,0.00001821159,0.00007046655,0.000313824,0.0003978328,0.0007806024,0.9136426,0.00006093465,0.001937674,0.00001512101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960116,0.001503068,0.0007724452,0.00007226179,0.00003257085,0.00002436375,0.0008536933,0.00002016158,0.0007097895],"genre_scores_gemma":[0.9900428,0.001894905,0.003111704,0.0001942431,0.00004387978,0.0001574919,0.001913197,0.00001219629,0.002629586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008680182,"threshold_uncertainty_score":0.002903819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414529038325354,"score_gpt":0.2817591996126783,"score_spread":0.2676139092294248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}