{"id":"W2158670312","doi":"10.1128/aac.01183-07","title":"Modulation of Gene Expression in Human Macrophages Treated with the Anti- <i>Leishmania</i> Pentavalent Antimonial Drug Sodium Stibogluconate","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Canada Research Chairs; Burroughs Wellcome Fund","keywords":"Sodium stibogluconate; Leishmania donovani; THP1 cell line; Biology; Amastigote; Meglumine antimoniate; Gene expression; Molecular biology; Leishmania; Gene expression profiling; Gene; Cutaneous leishmaniasis; Immunology; Cell culture; Leishmaniasis; Genetics; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003744217,0.0002317082,0.0004097425,0.0001484928,0.0001916553,0.00003348724,0.0001285931,0.00006843362,0.00005223962],"category_scores_gemma":[0.000004991864,0.0001433011,0.00006897654,0.000234724,0.0002659379,0.0001022651,0.00004840016,0.0001810949,0.000002067165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004274631,"about_ca_system_score_gemma":0.00002270629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003449237,"about_ca_topic_score_gemma":0.0001053793,"domain_scores_codex":[0.9985471,0.00005084344,0.0003474804,0.0003488262,0.0003280224,0.0003777061],"domain_scores_gemma":[0.9993619,0.00003587404,0.0001569448,0.0002525435,0.0001178082,0.00007492756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007832527,0.0003471887,0.2968933,0.00007498057,0.00008116232,0.00006690752,0.0009084891,0.000008245589,0.6946612,0.000003741649,0.004854921,0.001316587],"study_design_scores_gemma":[0.002997271,0.0001271468,0.5079406,0.0001112281,0.00001900167,0.00001724329,0.0001255121,0.00002950064,0.4878287,0.000002179963,0.0007041839,0.00009738745],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963204,0.00008240606,0.00009681025,0.002451567,0.00003619165,0.0006916023,0.00001188964,0.00002626635,0.0002829075],"genre_scores_gemma":[0.9968197,0.0009913977,0.0004029142,0.001139309,0.0001121197,0.00000486332,0.00003064527,0.00003846279,0.0004606043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2110474,"threshold_uncertainty_score":0.5843649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414529038325354,"score_gpt":0.2817591996126783,"score_spread":0.2676139092294248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}