{"id":"W2158686191","doi":"10.1186/1742-4690-10-6","title":"TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+T cells across the virological synapse","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Tetherin; Tetraspanin; Biology; Cell biology; Immunological synapse; SAMHD1; Immune system; Dendritic cell; T cell; Cytotoxic T cell; Virology; Cell; Immunology; Virus; Viral replication; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004880032,0.0002091214,0.0004316079,0.0001410472,0.0001820034,0.00001026011,0.0002543008,0.000395802,0.001624876],"category_scores_gemma":[0.0002433614,0.000142803,0.0001379245,0.0002535005,0.000599923,0.00006640803,0.0001889192,0.0004978438,0.0033658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000081809,"about_ca_system_score_gemma":0.00005703063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009908945,"about_ca_topic_score_gemma":0.00006288559,"domain_scores_codex":[0.997445,0.001006676,0.0004728257,0.0003552019,0.00008676887,0.0006334548],"domain_scores_gemma":[0.9983854,0.0007881719,0.0001848518,0.0004294296,0.0001437406,0.00006835125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003090606,0.000394453,0.01294429,0.00002929893,0.0002853542,0.000009615315,0.000461906,0.0001112529,0.9785965,0.0001104204,0.005683784,0.001064067],"study_design_scores_gemma":[0.003255028,0.00620759,0.2851654,0.0000222741,0.000111443,0.0000407953,0.0005022735,0.00002439442,0.6675215,0.00008771315,0.03679176,0.0002697567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965104,0.0004119969,0.000269139,0.001036042,0.0003942384,0.0009074067,0.0001814262,0.00004376454,0.0002455839],"genre_scores_gemma":[0.9982106,0.0005562717,0.00003936288,0.0003030297,0.00002262444,0.0001802497,0.0001185483,0.00001542212,0.0005538934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3110749,"threshold_uncertainty_score":0.9992878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616680412929029,"score_gpt":0.263741908692082,"score_spread":0.2475751045627917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}