{"id":"W2158690033","doi":"10.1186/1743-422x-4-60","title":"Porcine adenovirus type 3 E1Blarge protein downregulates the induction of IL-8","year":2007,"lang":"en","type":"article","venue":"Virology Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Molecular biology; Transcription (linguistics); Proinflammatory cytokine; Mutant; Luciferase; Adenoviridae; Electrophoretic mobility shift assay; Transcription factor; Viral vector; NFKB1; Mastadenovirus; Virology; Immune system; NF-κB; Gene; Cell biology; Genetic enhancement; Immunology; Transfection; Inflammation; Signal transduction; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009921411,0.0003064052,0.0001606748,0.000170769,0.00007909187,0.000314038,0.0001018714,0.000215041,0.001182728],"category_scores_gemma":[0.0001200501,0.0001139225,0.0002217897,0.00008150192,0.000218079,0.0001704654,0.0001200823,0.0004729518,0.0004466146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097112,"about_ca_system_score_gemma":0.0001543025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003748655,"about_ca_topic_score_gemma":0.0003286939,"domain_scores_codex":[0.9998906,0.00001820082,0.000009918645,0.00001541138,0.00002538469,0.00004054338],"domain_scores_gemma":[0.9998859,0.00003373251,0.00002572054,0.00001431873,0.00001147566,0.00002881566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006588243,0.00002668866,0.00009776336,0.00001407597,0.000001478916,0.00002242127,0.000007753196,0.00002123657,0.9993204,0.00004920278,0.0000195258,0.0003535831],"study_design_scores_gemma":[0.00003260559,0.0006397342,0.00590423,0.000009427404,0.00001277056,0.0002766569,0.00004197703,0.0009363135,0.9896175,0.00006599613,0.002458167,0.000004719156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965496,0.0006356505,0.001456061,0.00006021956,0.00002989594,0.00001017847,0.0001388565,0.00006395153,0.001055548],"genre_scores_gemma":[0.9957527,0.0004452952,0.001168692,0.00004086143,0.000009206891,0.00001207124,0.0004679562,0.0000141244,0.002089048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182728,"threshold_uncertainty_score":0.003956616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621183124961991,"score_gpt":0.2955377023713819,"score_spread":0.279325871121762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}