{"id":"W2158695106","doi":"10.1016/j.jchromb.2013.06.006","title":"A rapid and sensitive assay to quantify valproyl 1-O-acyl glucuronide in supernatants of sandwich-cultured rat hepatocytes using ultra-high performance liquid chromatography–tandem mass spectrometry","year":2013,"lang":"en","type":"article","venue":"Journal of Chromatography B","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chromatography; Glucuronidation; Selected reaction monitoring; Electrospray ionization; Tandem mass spectrometry; Mass spectrometry; Ion suppression in liquid chromatography–mass spectrometry; Glucuronide; Detection limit; Electrospray; High-performance liquid chromatography; Liquid chromatography–mass spectrometry; Metabolite; Microsome; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007996649,0.000405437,0.001371242,0.00105024,0.000128479,0.00005206232,0.0001749906,0.0001763397,0.00008163544],"category_scores_gemma":[0.0002259683,0.0002825742,0.0003816187,0.001384377,0.0003025641,0.0004197831,0.00005659894,0.0005458228,0.000003013886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007771636,"about_ca_system_score_gemma":0.0000854286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009477482,"about_ca_topic_score_gemma":0.000006256,"domain_scores_codex":[0.9972498,0.0002188249,0.0009933356,0.0003335471,0.000654232,0.0005501975],"domain_scores_gemma":[0.9981165,0.0003121201,0.0005394534,0.0001889315,0.0004536337,0.0003893977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007558571,0.0003181335,0.1602096,0.000272206,0.0006287948,0.0002100302,0.0004267067,0.00001293868,0.8364954,0.00001648354,0.0001681615,0.0004857386],"study_design_scores_gemma":[0.003624568,0.003427133,0.4202424,0.001049171,0.0002787074,0.000687114,0.0005356458,0.0003435474,0.569408,0.00004472138,0.00005958741,0.0002994278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949991,0.003100001,0.0002241825,0.0004148042,0.0002473256,0.0007949658,0.00001380194,0.00002814359,0.0001776566],"genre_scores_gemma":[0.9904788,0.003234189,0.00569269,0.0003786413,0.0001684373,0.00001119292,0.000002065538,0.00003069598,0.000003268537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2670874,"threshold_uncertainty_score":0.9999626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01994431798822295,"score_gpt":0.2801694331994631,"score_spread":0.2602251152112402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}