{"id":"W2158757667","doi":"10.1124/mol.107.036111","title":"The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Breast Cancer Research Alliance; Breast Cancer Alliance","keywords":"Chromatin immunoprecipitation; Molecular biology; Protein kinase B; Biology; Cell culture; Epidermal growth factor receptor; Growth inhibition; Cancer research; Cell growth; Phosphorylation; Receptor; Promoter; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Expression of concern","reason":"Concerns/Issues about Data;Error in Image;Error in Methods;Investigation by Company/Institution;Manipulation of Images;Misconduct - Official Investigation(s) and/or Finding(s);Misconduct by Author;Upgrade/Update of Prior Notice(s);","date":"7/6/2016 0:00","openalex_flagged":false},"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00277382,0.0009580398,0.001215491,0.0005970091,0.0008269824,0.0001694971,0.001139697,0.0007163805,0.003151877],"category_scores_gemma":[0.0009393347,0.0008068964,0.000516311,0.001098738,0.0006842491,0.0002898889,0.000809563,0.002520248,0.0006678876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001715678,"about_ca_system_score_gemma":0.0009640075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009847065,"about_ca_topic_score_gemma":0.00005595948,"domain_scores_codex":[0.9907687,0.001026715,0.001666408,0.001715292,0.002026531,0.002796314],"domain_scores_gemma":[0.9955882,0.001007256,0.0006040201,0.001067813,0.0005179656,0.001214738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001329091,0.0005116263,0.004444646,0.0001996802,0.0007826856,0.001988483,0.0004716699,0.000005555512,0.9655632,0.00005230329,0.004519363,0.02013168],"study_design_scores_gemma":[0.005575687,0.0007421879,0.002983896,0.0003206876,0.000317593,0.00009285969,0.0002913699,0.00004293893,0.9770532,0.0001162303,0.01169222,0.0007711707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819034,0.003943368,0.002118692,0.003347112,0.00304046,0.004377963,0.0002392901,0.0003258026,0.0007039344],"genre_scores_gemma":[0.9907236,0.0004490355,0.003069452,0.001475673,0.001565711,0.0006891137,0.0001614119,0.0003078588,0.001558211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01936051,"threshold_uncertainty_score":0.999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02589225735191017,"score_gpt":0.3415121767235288,"score_spread":0.3156199193716186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}