{"id":"W2158766590","doi":"10.1124/jpet.104.072421","title":"Comparative Study of Glucocorticoids, Cyclosporine A, and JTE-607 [(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-l-phenylalaninate Dihydrochloride] in a Mouse Septic Shock Model","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Gambling Research Exchange Ontario; Shionogi; Cell Science Research Foundation","keywords":"Proinflammatory cytokine; Myeloperoxidase; Prednisolone; Medicine; Cytokine; Methylprednisolone; Pharmacology; Septic shock; Immunosuppression; Subcutaneous injection; Immunology; Sepsis; Internal medicine; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437302,0.0006568206,0.0009072921,0.0006664929,0.0003166817,0.0003064428,0.0005341269,0.0006968321,0.001300552],"category_scores_gemma":[0.0003470794,0.0003618803,0.0008244291,0.0003726784,0.0007108648,0.0008272109,0.000162466,0.001336847,0.0003343436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002871764,"about_ca_system_score_gemma":0.0007098778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004467,"about_ca_topic_score_gemma":0.002112912,"domain_scores_codex":[0.9996697,0.00006469116,0.00002543896,0.0000531388,0.00005213556,0.0001350394],"domain_scores_gemma":[0.9995215,0.00006701936,0.00007865673,0.00005443982,0.00004162526,0.0002368261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02930218,0.003322312,0.0009662014,0.0002457455,0.0001436075,0.0003007126,0.00009377547,0.0003730184,0.9558101,0.0002749347,0.0002867445,0.008880702],"study_design_scores_gemma":[0.001429652,0.04845871,0.01013472,0.00002081376,0.0003923307,0.0003961653,0.0001544764,0.001267051,0.9355806,0.0001266751,0.001998656,0.0000401557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994065,0.003367074,0.000678981,0.0001925996,0.0001994103,0.00005594308,0.0003022389,0.0000775306,0.001061188],"genre_scores_gemma":[0.9940003,0.002517863,0.0007138518,0.00009217913,0.0001389545,0.00006548696,0.0004197746,0.00001791578,0.002033544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300552,"threshold_uncertainty_score":0.004350722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02425398700259436,"score_gpt":0.3307518109519031,"score_spread":0.3064978239493087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}