{"id":"W2158774304","doi":"10.1124/dmd.114.062877","title":"Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Glucuronidation; UGT2B7; Kidney; Chemistry; Glucuronosyltransferase; Endocrinology; Internal medicine; Metabolism; Enzyme; Biology; Biochemistry; Microsome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006139042,0.0002204339,0.0005162656,0.0001659314,0.0001654554,0.00002501604,0.00007651913,0.0001112862,0.00002310226],"category_scores_gemma":[0.00005624852,0.0002123249,0.00004437782,0.0001408098,0.0003775755,0.0003336271,0.00007013031,0.0002496676,0.000001086006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007522087,"about_ca_system_score_gemma":0.00006217149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001248484,"about_ca_topic_score_gemma":0.00001309751,"domain_scores_codex":[0.9984324,0.0004456506,0.0004100272,0.0002916425,0.0001897558,0.0002305237],"domain_scores_gemma":[0.9990398,0.0001186968,0.0002376468,0.0000945232,0.0001577729,0.0003516086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101539,0.0004385011,0.01801857,0.0002272612,0.0001237216,0.00000322857,0.00647585,0.00009681883,0.940802,0.01471779,0.0001587672,0.01783589],"study_design_scores_gemma":[0.003139026,0.0002456346,0.02370508,0.00004170484,0.0006333032,0.000009293639,0.0008921416,0.006364742,0.9619044,0.001086968,0.001717493,0.0002602291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879235,0.009943792,0.0005618753,0.0002204763,0.0002578226,0.0003494056,0.0003072777,0.00002238979,0.0004134707],"genre_scores_gemma":[0.9978498,0.0007995052,0.0009458669,0.0001117963,0.0001042974,0.00002061902,0.0001293833,0.00001623482,0.00002251849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02110233,"threshold_uncertainty_score":0.865836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113642258070508,"score_gpt":0.4387840570787291,"score_spread":0.3274198312716783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}