{"id":"W2158781569","doi":"10.1042/bj20070983","title":"Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Proteolysis; Chemistry; Cofactor; Biochemistry; Ubiquitin; Biophysics; Cytosol; Peptide sequence; Cysteine; Cleavage (geology); Plasma protein binding; Proteasome; Binding domain; Binding site; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001000843,0.0001483314,0.0002403064,0.0000856329,0.0002190277,0.00002707059,0.0002688656,0.0001267355,0.00004627592],"category_scores_gemma":[0.0001492391,0.00007434615,0.0001651691,0.0001844737,0.0005284864,0.00005493937,0.0000433131,0.0003854401,0.000003525623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006631285,"about_ca_system_score_gemma":0.0001469879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008857651,"about_ca_topic_score_gemma":0.0000027983,"domain_scores_codex":[0.9985137,0.00005606802,0.0004975218,0.000171589,0.000425043,0.0003360519],"domain_scores_gemma":[0.999306,0.00002234671,0.0002322437,0.0002314993,0.0001113685,0.00009656788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004183658,0.00008915527,0.0007031639,0.0001441076,0.00001084319,0.000005963562,0.0004740686,2.69706e-7,0.9958657,0.0006661618,0.001045047,0.0005771237],"study_design_scores_gemma":[0.001730359,0.00007663036,0.007504308,0.000545103,0.00002557336,0.00006946695,0.001488257,0.000001806479,0.9864582,0.0004124502,0.00158116,0.0001066979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902768,0.004958287,0.00003926089,0.002980084,0.00009742456,0.001427376,0.00000391174,0.000009262069,0.0002076152],"genre_scores_gemma":[0.9983926,0.00002311667,0.0005037512,0.0001949119,0.0003170333,0.0000314024,7.264346e-7,0.00001790711,0.0005185417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009407542,"threshold_uncertainty_score":0.3031748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04000305680623997,"score_gpt":0.2721229894158395,"score_spread":0.2321199326095995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}