{"id":"W2158858347","doi":"10.1002/bit.25598","title":"A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506)","year":2015,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"PLGA; Fibrin; Drug delivery; Pharmacology; Dorsal root ganglion; Reinnervation; Chemistry; Tacrolimus; Peripheral nerve injury; Biomedical engineering; Peripheral nerve; Transplantation; In vitro; Medicine; Surgery; Biochemistry; Anatomy; Dorsum; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289365,0.0003472094,0.0002442631,0.0003212371,0.000247181,0.0002602559,0.0002513324,0.0003848952,0.0006715111],"category_scores_gemma":[0.0001197859,0.0001345902,0.0002483861,0.0001654379,0.0001967801,0.0003884906,0.0001814632,0.0003237629,0.0002771903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003028504,"about_ca_system_score_gemma":0.0002348096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009322735,"about_ca_topic_score_gemma":0.0009921588,"domain_scores_codex":[0.9998965,0.000009735824,0.00001089947,0.00003194093,0.0000321753,0.00001874492],"domain_scores_gemma":[0.9999402,0.000008803245,0.00002528808,0.000005054434,0.000008900382,0.00001181723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004445735,0.00002906188,0.00004518158,0.0001024186,0.000004270913,0.00009302709,0.00001351589,0.0001431662,0.9875326,0.0001636928,0.0000769733,0.01175175],"study_design_scores_gemma":[0.00003694678,0.0009720667,0.001154363,0.00001391708,0.00004368229,0.0009425338,0.000009288848,0.002197905,0.9853989,0.00003295759,0.009178867,0.00001850253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8583624,0.0176059,0.1178909,0.0004797604,0.0003112823,0.0003595795,0.0003228882,0.0007974273,0.003869839],"genre_scores_gemma":[0.9422649,0.003729981,0.04937865,0.0001144828,0.00005791499,0.000176413,0.0001840858,0.00003345584,0.004060172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009322735,"threshold_uncertainty_score":0.002246439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801011948715414,"score_gpt":0.2243182832488465,"score_spread":0.2063081637616924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}