{"id":"W2158862125","doi":"10.1056/nejmoa1213917","title":"Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension","year":2013,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":1433,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Hospital; London Health Sciences Centre; Western University","funders":"Actelion Pharmaceuticals","keywords":"Medicine; Endothelin receptor antagonist; Pulmonary hypertension; Lung transplantation; Placebo; Bosentan; Clinical endpoint; Internal medicine; Cardiology; Hazard ratio; Confidence interval; Endothelin receptor; Anesthesia; Transplantation; Randomized controlled trial; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378661,0.0002799818,0.0003980967,0.0001694708,0.0001203377,0.0004057805,0.0002930804,0.0003466167,0.001459434],"category_scores_gemma":[0.002680537,0.0001200891,0.0005148987,0.0002024517,0.0002402117,0.0001657901,0.0002338268,0.0009611986,0.0001122312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336096,"about_ca_system_score_gemma":0.0002539105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463903,"about_ca_topic_score_gemma":0.0006844916,"domain_scores_codex":[0.9995351,0.0002713923,0.00003267304,0.00003796275,0.00007908645,0.00004385985],"domain_scores_gemma":[0.9973298,0.001275842,0.000900171,0.00007865921,0.00009295549,0.0003225559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1979042,0.002018821,0.6470589,0.002549089,0.004437824,0.0006144107,0.0001709654,0.002584214,0.007094074,0.0007560863,0.001827332,0.1329841],"study_design_scores_gemma":[0.008801865,0.01792751,0.9609892,0.0002445724,0.002595277,0.0008500978,0.00007287388,0.003649873,0.001369589,0.000804977,0.002665407,0.00002872322],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604825,0.03676582,0.0002925446,0.0005581046,0.0001007995,0.00003319034,0.0001498653,0.00001779445,0.001599446],"genre_scores_gemma":[0.9961978,0.003156642,0.0001052698,0.0001007932,0.0001246159,0.00001577379,0.0001046414,0.000001868289,0.0001926307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459434,"threshold_uncertainty_score":0.007291138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04315870017816357,"score_gpt":0.3016081234936187,"score_spread":0.2584494233154551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}