{"id":"W2158882181","doi":"10.1128/jvi.00182-09","title":"Human Immunodeficiency Virus Type 1-Specific CD8<sup>+</sup>T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4<sup>+</sup>T Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Doris Duke Charitable Foundation; University of California, San Francisco; Howard Hughes Medical Institute","keywords":"Biology; Virology; CD8; Lentivirus; Virus; Human immunodeficiency virus (HIV); Molecular biology; Viral disease; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005744772,0.0002401714,0.0006577776,0.0003484786,0.0002778795,0.00001262509,0.0003188631,0.000300932,0.0001790238],"category_scores_gemma":[0.00006943847,0.0001662726,0.0002196747,0.0001818902,0.0005390281,0.0001446578,0.0001393206,0.0006211709,0.00004725673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048386,"about_ca_system_score_gemma":0.0001287541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000669092,"about_ca_topic_score_gemma":0.00001208556,"domain_scores_codex":[0.9975807,0.0007585844,0.0008333969,0.0002426364,0.0001248408,0.000459861],"domain_scores_gemma":[0.9984497,0.0001696226,0.0007628186,0.0003720855,0.0001966553,0.00004911373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003181531,0.0007673495,0.05513296,0.00006198185,0.000135546,0.0001347736,0.0008303979,0.0002233527,0.9383475,0.00001360396,0.0004443962,0.0007265683],"study_design_scores_gemma":[0.004543924,0.004729419,0.5435015,0.000103639,0.0001125922,0.001334019,0.0002056851,0.0000091642,0.443916,0.0001766429,0.001191864,0.0001755854],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939668,0.005279391,0.000006689701,0.0001466687,0.0001505593,0.0002236942,0.00008499641,0.00000858756,0.0001325739],"genre_scores_gemma":[0.9981855,0.001126839,0.00003706991,0.00006594671,0.00003960934,0.000002401042,0.000007590214,0.00001552508,0.000519481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4944316,"threshold_uncertainty_score":0.6780399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350141807171674,"score_gpt":0.2609607489621165,"score_spread":0.2474593308903998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}