{"id":"W2158882181","doi":"10.1128/jvi.00182-09","title":"Human Immunodeficiency Virus Type 1-Specific CD8<sup>+</sup>T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4<sup>+</sup>T Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Doris Duke Charitable Foundation; University of California, San Francisco; Howard Hughes Medical Institute","keywords":"Biology; Virology; CD8; Lentivirus; Virus; Human immunodeficiency virus (HIV); Molecular biology; Viral disease; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304535,0.0002271655,0.0002199938,0.0001549166,0.0001738053,0.0002322298,0.00009725636,0.0001686793,0.001659175],"category_scores_gemma":[0.0003449749,0.0001345729,0.00008186599,0.0001262174,0.0001933342,0.0001347856,0.0001165961,0.0002877893,0.0004236478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000107435,"about_ca_system_score_gemma":0.00008707466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005698983,"about_ca_topic_score_gemma":0.000545684,"domain_scores_codex":[0.9999026,0.00001984467,0.000005979439,0.0000299935,0.00001538807,0.00002618168],"domain_scores_gemma":[0.9997916,0.0000552614,0.00005537181,0.00002235739,0.00002899775,0.00004643214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001139651,0.0002242989,0.4136788,0.0001126448,0.00004665982,0.0005896665,0.0005906976,0.0003271317,0.5569724,0.00008227262,0.0002334723,0.02600241],"study_design_scores_gemma":[0.00002320957,0.001343632,0.9666277,0.00001124189,0.00002608315,0.001678989,0.0002015622,0.0003229004,0.02863204,0.00006785065,0.001058499,0.000006316965],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992312,0.0001769915,0.0001616335,0.000006894693,0.000001595328,0.00001316971,0.00007687785,0.000007484047,0.0003242072],"genre_scores_gemma":[0.9989771,0.00008469705,0.0001386545,0.00001630545,0.000005174141,0.0000173868,0.0001654613,0.00000321427,0.0005921577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659175,"threshold_uncertainty_score":0.005550504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350141807171674,"score_gpt":0.2609607489621165,"score_spread":0.2474593308903998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}