{"id":"W2158898951","doi":"10.1371/journal.pone.0041033","title":"Toll-Like Signaling and the Cytokine IL-6 Regulate Histone Deacetylase Dependent Neuronal Survival","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Histone deacetylase; Cell biology; Signal transduction; Biology; Cytokine; Histone deacetylase inhibitor; Receptor; Cancer research; Histone; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090694,0.0002832245,0.000220881,0.000166483,0.0001281813,0.0002817299,0.0001650862,0.0002196262,0.001436069],"category_scores_gemma":[0.0001047902,0.0001423412,0.0003072989,0.0001054893,0.000211614,0.0002008406,0.0001685034,0.00041097,0.0004342489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702371,"about_ca_system_score_gemma":0.0001893625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003096201,"about_ca_topic_score_gemma":0.001088657,"domain_scores_codex":[0.9998739,0.00001948587,0.00001093247,0.00002440308,0.00002937608,0.0000419188],"domain_scores_gemma":[0.9999316,0.000008661342,0.00002397152,0.000007936582,0.00001108128,0.00001678701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190232,0.00001428447,0.000282627,0.00004262381,0.000008113874,0.00002835864,0.000007364195,0.0000385419,0.9970921,0.00009345103,0.00003798129,0.002164439],"study_design_scores_gemma":[0.00002031715,0.0002063666,0.0119867,0.000006332131,0.00001820669,0.0001431697,0.00002777865,0.0004027403,0.9846352,0.0001061602,0.002442823,0.000004313298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698616,0.01776414,0.007302371,0.0003531491,0.0001128719,0.00004169954,0.000694704,0.0001010335,0.003768569],"genre_scores_gemma":[0.9875321,0.005397616,0.003539722,0.0001125517,0.00002759218,0.00003719274,0.0004847012,0.00001295839,0.002855564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001436069,"threshold_uncertainty_score":0.004804075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02973787025419298,"score_gpt":0.2582996330271828,"score_spread":0.2285617627729899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}