{"id":"W2158902266","doi":"10.1111/j.1749-6632.2001.tb04039.x","title":"Developing a SERM: Stringent Preclinical Selection Criteria Leading to an Acceptable Candidate (WAY‐140424) for Clinical Evaluation","year":2001,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Raloxifene; Selective estrogen receptor modulator; Osteoporosis; Hormone replacement therapy (female-to-male); Medicine; Pharmacology; Estrogen; Breast cancer; Estrogen receptor; Internal medicine; Bioinformatics; Endocrinology; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005011796,0.001208891,0.001961147,0.001723157,0.0005739667,0.001872421,0.001165922,0.001864443,0.01729221],"category_scores_gemma":[0.004521681,0.0005544247,0.001158714,0.0005994387,0.0007840706,0.001145773,0.001164113,0.002588635,0.008313298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005995136,"about_ca_system_score_gemma":0.002982325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004265855,"about_ca_topic_score_gemma":0.001348488,"domain_scores_codex":[0.99803,0.0006762259,0.0001613443,0.0002364959,0.0007023889,0.000193499],"domain_scores_gemma":[0.9985377,0.0002642382,0.000210142,0.0001359506,0.0005047399,0.0003473237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008169468,0.003689619,0.003562117,0.003235637,0.0003069038,0.002047588,0.0003305282,0.002699767,0.6011164,0.008754405,0.036159,0.3299285],"study_design_scores_gemma":[0.00610319,0.06150449,0.01195198,0.001125648,0.001022382,0.006299256,0.0003272839,0.005669173,0.3242987,0.004379392,0.5770196,0.0002989375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4535203,0.07483159,0.2649458,0.0153319,0.003248616,0.05221766,0.01384585,0.005967187,0.1160911],"genre_scores_gemma":[0.6042534,0.03760942,0.2359376,0.01045791,0.001238261,0.02309782,0.0146849,0.001185369,0.07153536],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01729221,"threshold_uncertainty_score":0.05784816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3863279180487043,"score_gpt":0.5453916230703003,"score_spread":0.1590637050215961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}