{"id":"W2158902266","doi":"10.1111/j.1749-6632.2001.tb04039.x","title":"Developing a SERM: Stringent Preclinical Selection Criteria Leading to an Acceptable Candidate (WAY‐140424) for Clinical Evaluation","year":2001,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Raloxifene; Selective estrogen receptor modulator; Osteoporosis; Hormone replacement therapy (female-to-male); Medicine; Pharmacology; Estrogen; Breast cancer; Estrogen receptor; Internal medicine; Bioinformatics; Endocrinology; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004673834,0.0002535704,0.0007916362,0.0001129618,0.0002135317,0.00003795197,0.0009594443,0.0006610464,0.00001043188],"category_scores_gemma":[0.0007269896,0.0001696933,0.0004861125,0.0006350914,0.0002494065,0.00001902596,0.0002028225,0.0002895583,0.000002784598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001967424,"about_ca_system_score_gemma":0.0008034644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002596901,"about_ca_topic_score_gemma":0.000007254082,"domain_scores_codex":[0.9971023,0.0005114092,0.0009925751,0.0006362246,0.0003910681,0.000366413],"domain_scores_gemma":[0.9986398,0.0001425107,0.0007830533,0.0001546293,0.0001183902,0.0001615648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006813031,0.0000529179,0.00008230052,0.0006369375,0.0001943625,3.36125e-8,0.00003645521,0.0001016206,0.001051686,0.00007140573,0.01216553,0.9855386],"study_design_scores_gemma":[0.0003267771,0.001228492,0.0001154762,0.003693256,0.000532847,0.00001594086,0.00003260324,0.0002234698,0.02388106,0.0004425771,0.9691182,0.000389261],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03260431,0.9641818,0.0002396691,0.0007585364,0.0004152693,0.001675723,0.00002478358,0.00000931455,0.00009061466],"genre_scores_gemma":[0.004471403,0.9916694,0.002443834,0.000328907,0.0006694486,0.00005762261,0.00002836106,0.00002322707,0.0003078409],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9851494,"threshold_uncertainty_score":0.6919893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3863279180487043,"score_gpt":0.5453916230703003,"score_spread":0.1590637050215961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}