{"id":"W2158958901","doi":"10.1016/j.ccr.2010.06.003","title":"PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":338,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health; Institut Universitaire de France; National Institute of Diabetes and Digestive and Kidney Diseases; Ligue Contre le Cancer; European Commission","keywords":"SUMO protein; Chemistry; Cell biology; Acute promyelocytic leukemia; Promyelocytic leukemia protein; Reactive oxygen species; Biogenesis; HEK 293 cells; Ubiquitin; Biology; Biochemistry; Retinoic acid; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604491,0.00009489332,0.00008440212,0.00001642818,0.000068972,0.00001800441,0.0001497107,0.0001228773,0.00005377008],"category_scores_gemma":[0.00005765074,0.00007202099,0.00003701407,0.00005025839,0.0001430258,0.000005751306,0.00006185393,0.0001180545,0.000003292409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001143334,"about_ca_system_score_gemma":0.0001837176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003499372,"about_ca_topic_score_gemma":0.0000322728,"domain_scores_codex":[0.9994033,0.00005276726,0.0001377976,0.0001957349,0.00007793217,0.0001324935],"domain_scores_gemma":[0.9995185,0.00003123542,0.000102972,0.0002514569,0.00005972583,0.00003613369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141183,0.000008543801,0.001923743,0.00003695492,0.000009878047,0.000001042772,0.0001004641,0.000005583799,0.9961069,0.00001928005,0.0003400367,0.0013064],"study_design_scores_gemma":[0.0003061164,0.00006434198,0.001556078,0.00001129603,0.0000184373,0.000007113384,0.00009294054,0.00002334627,0.9828903,0.00003822719,0.01489659,0.00009520668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995566,0.002305248,0.0001327591,0.00004509427,0.000224871,0.00008981657,0.00001114398,0.000005613017,0.00161952],"genre_scores_gemma":[0.9968995,0.001729396,0.0001418731,0.00009570278,0.0001425847,0.00001666331,0.00002026425,0.00001440755,0.0009396021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01455656,"threshold_uncertainty_score":0.2936931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006155186415695392,"score_gpt":0.2460938627580414,"score_spread":0.239938676342346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}