{"id":"W2158967755","doi":"10.1074/jbc.m111381200","title":"Crystal Structure of the MexR Repressor of themexRAB-oprM Multidrug Efflux Operon of Pseudomonas aeruginosa","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Repressor; Operon; Effector; Biology; Efflux; DNA; Pseudomonas aeruginosa; Context (archaeology); Genetics; Biochemistry; Gene; Transcription factor; Bacteria; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638233,0.0004225109,0.0006436865,0.000197655,0.0008272345,0.0008086802,0.0007005232,0.0004640014,0.002439109],"category_scores_gemma":[0.000563818,0.0002803018,0.0001758579,0.0004101592,0.0002388328,0.0003982744,0.0002763336,0.001665624,0.000476622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001448539,"about_ca_system_score_gemma":0.001084937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00735584,"about_ca_topic_score_gemma":0.01247668,"domain_scores_codex":[0.9998332,0.00002108426,0.000006162645,0.00002569386,0.00007742876,0.0000362857],"domain_scores_gemma":[0.9998042,0.00004045641,0.00003128962,0.000005974063,0.00005643024,0.0000616879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002900293,0.001677829,0.0190616,0.002650638,0.0005746106,0.005585727,0.001642732,0.02051197,0.821945,0.0091824,0.06563952,0.04862768],"study_design_scores_gemma":[0.005069341,0.002485479,0.2079301,0.0006606063,0.001031588,0.006926331,0.004865483,0.2790982,0.2386487,0.006966646,0.2457933,0.0005241969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703552,0.01172465,0.002154729,0.002837938,0.0002548939,0.00008000929,0.003263116,0.0004095388,0.008919897],"genre_scores_gemma":[0.965114,0.00601565,0.005682562,0.0006791013,0.00008371071,0.0001079318,0.01542392,0.0001395171,0.006753609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00735584,"threshold_uncertainty_score":0.01462603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488452972208924,"score_gpt":0.2371919872272011,"score_spread":0.2223074575051118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}