{"id":"W2158973015","doi":"10.1086/587993","title":"Safety and Immunogenicity of a Replication‐Incompetent Adenovirus Type 5 HIV‐1 Clade B<i>gag/pol/nef</i>Vaccine in Healthy Adults","year":2008,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; Center for AIDS Research, University of Washington; International AIDS Vaccine Initiative; National Institutes of Health; School of Medicine, New York University; York University","keywords":"Immunogenicity; Medicine; Virology; Adverse effect; ELISPOT; HIV vaccine; Neutralizing antibody; Placebo; Virus; Immunology; Regimen; Antibody; Vaccination; Immune system; Vaccine trial; Internal medicine; T cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001611505,0.0003091281,0.000529148,0.000101257,0.0001869256,0.0002494401,0.0002005539,0.0005960381,0.0006643226],"category_scores_gemma":[0.001763087,0.0001540848,0.0003389135,0.00009682884,0.0003127419,0.000297161,0.0001246266,0.0004930177,0.0001454306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461949,"about_ca_system_score_gemma":0.000307473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001510839,"about_ca_topic_score_gemma":0.0001347853,"domain_scores_codex":[0.9995111,0.0002827914,0.00004025346,0.00006953252,0.00006169706,0.00003458449],"domain_scores_gemma":[0.999087,0.0003391235,0.00033751,0.00003827399,0.00006672359,0.0001314355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4592093,0.01784015,0.18432,0.00228901,0.001609934,0.000728625,0.0009716181,0.001777294,0.09294891,0.0002494418,0.001699387,0.2363563],"study_design_scores_gemma":[0.05871364,0.7618265,0.1628923,0.0001365263,0.0007691555,0.001115979,0.0001700502,0.001318988,0.01049058,0.0002134652,0.002329526,0.00002321541],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998372,0.00110127,0.0001440848,0.00005683042,0.00001179838,0.00007913151,0.00005458785,0.000005679702,0.0001747381],"genre_scores_gemma":[0.9988338,0.000404426,0.0002614623,0.000147294,0.00003910455,0.0001107165,0.000117725,0.000001545679,0.00008394419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611505,"threshold_uncertainty_score":0.008522511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02940967443426321,"score_gpt":0.3595694906119105,"score_spread":0.3301598161776473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}