{"id":"W2158990411","doi":"10.1128/mbio.00377-13","title":"The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, <i>H</i> 30-Rx","year":2013,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; School of Medicine, University of Missouri; NorthShore University HealthSystem; University of Washington; University of Pennsylvania; Seattle Children's Research Institute; Hennepin County Medical Center; University of Minnesota; University of Missouri; National Institute of Allergy and Infectious Diseases; Tufts University School of Medicine; Children’s Hospital of Wisconsin Research Institute; Medical Research and Materiel Command; Office of Research and Development; Calgary Laboratory Services; University of Miami; U.S. Department of Veterans Affairs","keywords":"Pulsed-field gel electrophoresis; Escherichia coli; Biology; Plasmid; clone (Java method); Mobile genetic elements; Genome; Whole genome sequencing; Microbiology; Virulence; Genetics; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161247,0.0003141791,0.0001675243,0.0002094379,0.0001483931,0.000294078,0.0002504185,0.0002891159,0.0007612851],"category_scores_gemma":[0.0003595153,0.0000887572,0.0001906951,0.0002598401,0.0002613333,0.0001779819,0.0003916843,0.0003335467,0.0002302987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003084545,"about_ca_system_score_gemma":0.0003773351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00223537,"about_ca_topic_score_gemma":0.002027486,"domain_scores_codex":[0.9998263,0.00001721784,0.00001315949,0.00005882154,0.00004962557,0.00003504201],"domain_scores_gemma":[0.9997485,0.00003440091,0.0001056421,0.00002251119,0.00004657694,0.00004238186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000235988,0.00004371042,0.04735405,0.00006723579,0.00003018613,0.0003190142,0.00009618582,0.0002363608,0.9419949,0.000165681,0.0001913997,0.009265197],"study_design_scores_gemma":[0.00005382122,0.001359319,0.6889685,0.00003179625,0.0001196879,0.004700158,0.0003751319,0.004853561,0.294219,0.0003772735,0.004905518,0.00003619587],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972659,0.0001831316,0.001636978,0.00006415485,0.00000595876,0.00002415541,0.0002035435,0.00004744592,0.0005687918],"genre_scores_gemma":[0.9965527,0.000205106,0.002061289,0.00007317557,0.00001437174,0.00001290175,0.0007652924,0.00001081501,0.0003043652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00223537,"threshold_uncertainty_score":0.004444659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0072431844875578,"score_gpt":0.2158028103529039,"score_spread":0.2085596258653461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}