{"id":"W2159004238","doi":"10.1152/ajprenal.00067.2005","title":"Cadmium inhibits both intrinsic and extrinsic apoptotic pathways in renal mesangial cells","year":2005,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"","keywords":"Mesangial cell; Apoptosis; Cell biology; Caspase 3; Chemistry; DNA laddering; Caspase; Cytochrome c; Caspase 8; Camptothecin; DNA fragmentation; Molecular biology; Programmed cell death; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115512,0.0003052954,0.0002533717,0.0001603729,0.0001456713,0.0001789188,0.0001205079,0.0001577381,0.0007490463],"category_scores_gemma":[0.0001069634,0.00007389436,0.0001708806,0.0001048665,0.0001232946,0.0001454458,0.0001821114,0.0003350919,0.0002037412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198592,"about_ca_system_score_gemma":0.0002082287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003605596,"about_ca_topic_score_gemma":0.001196521,"domain_scores_codex":[0.99989,0.00002327492,0.00001239172,0.00001231004,0.00003400507,0.00002801676],"domain_scores_gemma":[0.9999151,0.00001427533,0.00001844114,0.00001204035,0.00002142359,0.00001861786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002028947,0.00004191088,0.0003741054,0.0001027332,0.00001064878,0.00006049688,0.0000228355,0.00006943998,0.9965923,0.00006395409,0.00005675087,0.002401831],"study_design_scores_gemma":[0.00003885151,0.0006231787,0.008243523,0.0000105032,0.00002448519,0.0002723352,0.00004255462,0.0004780244,0.9866319,0.0000584565,0.00357219,0.000004006898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874157,0.00725178,0.002609317,0.0001606457,0.00005505973,0.00002727456,0.0002685415,0.0001055854,0.002106003],"genre_scores_gemma":[0.992052,0.003710222,0.001309749,0.00008576442,0.00001953734,0.00002436029,0.0003438787,0.000007872328,0.002446631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007490463,"threshold_uncertainty_score":0.002505839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008157343672785117,"score_gpt":0.2176080407687412,"score_spread":0.2094506970959561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}