{"id":"W2159014577","doi":"10.4049/jimmunol.0903476","title":"A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Oncostatin M; STAT6; Pulmonary Eosinophilia; Eotaxin; Pathology; Goblet cell; Eosinophilia; Eosinophil; Interleukin 13; Fibrosis; Pulmonary fibrosis; Cytokine; Immunology; Medicine; Biology; Inflammation; Interleukin 4; Chemokine; Interleukin 6; Epithelium; Asthma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000417304,0.001625411,0.0007081088,0.00159994,0.0005664874,0.0005107886,0.0006443639,0.001856507,0.004283025],"category_scores_gemma":[0.0001359554,0.0005384348,0.0009169849,0.0006354771,0.0008498499,0.000832382,0.0005248977,0.002754888,0.001326231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005610874,"about_ca_system_score_gemma":0.0003543151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005333493,"about_ca_topic_score_gemma":0.001230242,"domain_scores_codex":[0.9994746,0.0000691212,0.00007209786,0.0001356383,0.0001437478,0.000104882],"domain_scores_gemma":[0.9995711,0.00003180172,0.0001425362,0.00004233725,0.00003303347,0.0001792317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007817781,0.000415657,0.0006258103,0.0001171555,0.0000208921,0.0004948351,0.00005591137,0.0001084622,0.9943433,0.0005208274,0.0003674671,0.002148073],"study_design_scores_gemma":[0.0007813594,0.006970728,0.0232055,0.0001077198,0.0001861264,0.01053972,0.0002466498,0.004353304,0.9250393,0.0008221816,0.02767253,0.00007482048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641483,0.002967532,0.01654845,0.00129202,0.0003735375,0.0006435059,0.00699349,0.00116747,0.005865585],"genre_scores_gemma":[0.9335614,0.003411273,0.01965129,0.0007102711,0.0001403687,0.001525503,0.008935937,0.0002417108,0.03182226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004283025,"threshold_uncertainty_score":0.01432812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195610221461521,"score_gpt":0.2455171527789209,"score_spread":0.2335610505643057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}