{"id":"W2159036513","doi":"10.1128/aac.44.6.1609-1615.2000","title":"Absolute Bioavailability and Disposition of (−) and (+) 2′-Deoxy- 3′-Oxa-4′-Thiocytidine (dOTC) following Single Intravenous and Oral Doses of Racemic dOTC in Humans","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Pharmacokinetics; Chemistry; Bioavailability; Volume of distribution; Steady state (chemistry); Coefficient of variation; Pharmacology; Chromatography; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000406696,0.0002128561,0.0004788954,0.0001127541,0.0001172175,0.0003067205,0.00008886864,0.0003675352,0.0005770197],"category_scores_gemma":[0.0008461867,0.0002692444,0.0001400235,0.00009858291,0.0002640681,0.0002216384,0.0000633278,0.0003520291,0.0002226559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881717,"about_ca_system_score_gemma":0.0001608005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082025,"about_ca_topic_score_gemma":0.000713692,"domain_scores_codex":[0.9997841,0.0000708673,0.0000117015,0.00008286049,0.00003731077,0.00001320389],"domain_scores_gemma":[0.9997527,0.00006795506,0.00008721335,0.00004448228,0.00002412374,0.00002360072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04589096,0.0006795432,0.07265112,0.0002276864,0.0005489224,0.0007055405,0.0005468777,0.003689961,0.7829635,0.0004557841,0.0008439529,0.09079615],"study_design_scores_gemma":[0.00205506,0.06480952,0.6523668,0.00004163758,0.0009289851,0.008962774,0.0003807419,0.02583291,0.2356173,0.0007005186,0.008184157,0.0001195462],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965964,0.001399774,0.001559147,0.00001888501,0.000005797639,0.00001207232,0.0001463121,0.00002271476,0.0002389504],"genre_scores_gemma":[0.9981322,0.0004252334,0.0008088502,0.00005209938,0.0000149048,0.00001754437,0.0002026356,0.000009450966,0.0003371053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082025,"threshold_uncertainty_score":0.00215143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239263603357221,"score_gpt":0.255528225462565,"score_spread":0.2431355894289928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}