{"id":"W2159046107","doi":"10.1107/s0907444901001160","title":"Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3α-hydroxysteroid dehydrogenase at 1.8 Å resolution","year":2001,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Wilfrid Laurier University; Medical Council of Canada","funders":"","keywords":"Crystallography; Dehydrogenase; Crystallization; Hydroxysteroid dehydrogenase; Dihydrotestosterone; Monoclinic crystal system; Chemistry; Androgen receptor; Resolution (logic); Crystal structure; Androgen; Oxidoreductase; Crystal (programming language); Stereochemistry; Enzyme; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008539615,0.0008318939,0.001087602,0.0002992484,0.000600466,0.001054798,0.001088992,0.0007122213,0.00142273],"category_scores_gemma":[0.0010963,0.0003595705,0.0005755021,0.001299508,0.0002753836,0.0004082768,0.0002458638,0.00146268,0.001019251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001133504,"about_ca_system_score_gemma":0.0009734292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007889581,"about_ca_topic_score_gemma":0.006638021,"domain_scores_codex":[0.9996081,0.0001007836,0.00003724519,0.00006533725,0.0001196765,0.00006880833],"domain_scores_gemma":[0.9996572,0.00007000768,0.00003286644,0.00003356751,0.00012459,0.00008190958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004260307,0.0008972037,0.007964355,0.002906539,0.0003792078,0.00458707,0.002092387,0.01758464,0.8383042,0.006006481,0.04427258,0.07074503],"study_design_scores_gemma":[0.001172424,0.00139573,0.05766188,0.0003597685,0.0004541221,0.004573914,0.001439855,0.030362,0.5091515,0.004456138,0.388697,0.0002756815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8640697,0.05474178,0.02196838,0.003794099,0.001150992,0.0009352256,0.03366115,0.0009544374,0.01872422],"genre_scores_gemma":[0.7403172,0.05147862,0.07367616,0.001017844,0.0003212219,0.0005546186,0.1116797,0.0003450599,0.0206096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007889581,"threshold_uncertainty_score":0.01568729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433702145783796,"score_gpt":0.2367111821468886,"score_spread":0.2223741606890506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}