{"id":"W2159068988","doi":"10.2174/0929867023371102","title":"Methionine In and Out of Proteins: Targets for Drug Design","year":2002,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Enzyme; Methionine; Biochemistry; Antibiotics; Drug development; Biology; Drug discovery; Computational biology; Aminopeptidase; Amino acid; Drug; Chemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004411198,0.001018743,0.001594662,0.001306058,0.0002856418,0.000906061,0.0009143192,0.001112209,0.002906439],"category_scores_gemma":[0.0002598951,0.000330658,0.0003804498,0.001134927,0.0005823305,0.001703036,0.0004724312,0.001633951,0.003303498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006868012,"about_ca_system_score_gemma":0.0005201909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510281,"about_ca_topic_score_gemma":0.0008134231,"domain_scores_codex":[0.9998522,0.00002885156,0.00001261996,0.00002578564,0.00006110778,0.00001932991],"domain_scores_gemma":[0.9999143,0.00002901326,0.00001535771,0.000005344154,0.00002036308,0.00001561391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00021921,0.0002136587,0.0001773514,0.007261685,0.00007113286,0.0007803121,0.0001243196,0.002528364,0.03333217,0.02092306,0.02960799,0.9047607],"study_design_scores_gemma":[0.0001021134,0.000283474,0.0003629058,0.0008605575,0.00004907564,0.001660029,0.00007377461,0.0007797002,0.007061698,0.009780192,0.9789613,0.00002513878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001235433,0.988979,0.003259477,0.001168905,0.0004601103,0.00003309102,0.00005013325,0.00006130662,0.004752414],"genre_scores_gemma":[0.006339616,0.9859269,0.002963896,0.0006753945,0.0002854542,0.00004014494,0.00008204686,0.000007332778,0.00367915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002906439,"threshold_uncertainty_score":0.009723008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1317090353319891,"score_gpt":0.3967242398192432,"score_spread":0.265015204487254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}