{"id":"W2159092790","doi":"10.1128/aem.00094-08","title":"Cysteine Scanning Mutagenesis of α4, a Putative Pore-Lining Helix of the <i>Bacillus thuringiensis</i> Insecticidal Toxin Cry1Aa","year":2008,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Biotechnology Research Institute; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Manduca sexta; Midgut; Bacillus thuringiensis; Brush border; Mutant; Cysteine; Biology; Biochemistry; Toxin; Mutagenesis; Bombyx mori; Amino acid; Wild type; Vesicle; Microbiology; Biophysics; Insect; Bacteria; Larva; Enzyme; Membrane; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656355,0.0005545504,0.0002932218,0.0002407762,0.0002596279,0.0002243041,0.0003596236,0.0003006978,0.001092253],"category_scores_gemma":[0.0003578195,0.0001722552,0.0004045706,0.000259375,0.0003507566,0.0001735124,0.0002574253,0.0004739476,0.0004272328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004909257,"about_ca_system_score_gemma":0.0003477461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469922,"about_ca_topic_score_gemma":0.001481241,"domain_scores_codex":[0.9997839,0.00007146032,0.00003058905,0.00003830697,0.00004849262,0.00002716651],"domain_scores_gemma":[0.9997062,0.00007771757,0.0001039401,0.00003149271,0.00003971023,0.00004092265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000346989,0.00004831468,0.0005455964,0.00007492308,0.0000239382,0.0003156877,0.00004749655,0.0004354526,0.9961296,0.0001995685,0.00005174119,0.00178059],"study_design_scores_gemma":[0.00008776515,0.0006712929,0.007203764,0.00002265208,0.00007823166,0.001107793,0.0000676659,0.00188785,0.9855543,0.0001075274,0.003192751,0.00001828575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935256,0.0003283639,0.004266151,0.00005937179,0.00004028564,0.0001060607,0.0004077253,0.0000545821,0.001211796],"genre_scores_gemma":[0.9934255,0.0002605467,0.004268918,0.00004063609,0.00001279232,0.00003215285,0.0006765875,0.0000295369,0.001253413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001469922,"threshold_uncertainty_score":0.003653944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004808457965092229,"score_gpt":0.1714590318365397,"score_spread":0.1666505738714475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}