{"id":"W2159092790","doi":"10.1128/aem.00094-08","title":"Cysteine Scanning Mutagenesis of α4, a Putative Pore-Lining Helix of the <i>Bacillus thuringiensis</i> Insecticidal Toxin Cry1Aa","year":2008,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Biotechnology Research Institute; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Manduca sexta; Midgut; Bacillus thuringiensis; Brush border; Mutant; Cysteine; Biology; Biochemistry; Toxin; Mutagenesis; Bombyx mori; Amino acid; Wild type; Vesicle; Microbiology; Biophysics; Insect; Bacteria; Larva; Enzyme; Membrane; Genetics; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007622354,0.0001650746,0.0002302023,0.0000276311,0.0001178852,0.000001850247,0.000136935,0.0001519179,0.000008210629],"category_scores_gemma":[0.000007076433,0.0001314378,0.00008054036,0.0000531564,0.0006438348,0.000001856962,0.0002141016,0.00007737351,0.000001476874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001285504,"about_ca_system_score_gemma":0.00002585159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001732975,"about_ca_topic_score_gemma":0.00001016834,"domain_scores_codex":[0.9991419,0.00004130913,0.0002695798,0.0002836154,0.00004875965,0.0002148124],"domain_scores_gemma":[0.9995504,0.00001625617,0.0001691233,0.0002230849,0.000008244898,0.00003287748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009799133,0.00005310915,0.005354994,0.00001943205,0.0000631912,0.000002813608,0.0004359723,0.000182681,0.9932269,0.00001708589,0.00004394886,0.0005018324],"study_design_scores_gemma":[0.0006078065,0.0002541503,0.01199478,0.000008923575,0.00002610172,0.0001568811,0.0004577229,0.000003727982,0.984975,0.00001836052,0.001353299,0.0001431856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979329,0.00117198,0.0001130637,0.00001865776,0.00005848645,0.0001616019,0.0001041056,0.000003277479,0.000435925],"genre_scores_gemma":[0.9985899,0.000385941,0.0004908912,0.000206576,0.00004724678,0.00001042797,0.0001161797,0.00001679057,0.0001360487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008251884,"threshold_uncertainty_score":0.535988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004808457965092229,"score_gpt":0.1714590318365397,"score_spread":0.1666505738714475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}